Now showing items 1101-1106 of 1106
Characterization and Elimination of the HIV Reservoir
(2018)
The current HIV epidemic is highlighted by the remarkable success of combination anti-retroviral therapy (cART). Unfortunately, life-long and continuous cART is necessary for infected individuals due to persistent HIV ...
Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits
(2018)
The first discovery of a growth-regulating signaling molecule was more than 65 years ago, when the work of Rita Levi-Montalcini, Viktor Hamburger, and Stanley Cohen led to the identification and purification of nerve growth ...
Sexual Deprivation, Emotion, and Longevity: Neuropeptidergic Regulation of Aging in Drosophila
(2018)
While researchers often focus on the brain as a victim of aging via neurodegenerative diseases, recent work has demonstrated that the aging process is regulated by neural mechanisms. Thus, we asked which mechanisms and ...
Nucleotide and Polymerization Effects on Actin Structure and Dynamics
(2018)
Actin is one of the most highly conserved and abundant proteins found in eukaryotic cells, essential for determining cell shape, polarity and motility, as well as protein transport and even mitosis and muscle contraction. ...
Role of TH2 Cytokines in Regulatory B Cell Biology
(2018)
B cells are now appreciated to be far more than antibody secreting cells. Throughout the last two decades B cells have been described to utilize a vast array of mechanisms to influence immune responses. Immune tolerance ...
Development and Application of Virtual Screening Methods for G Protein-Coupled Receptors
(2018)
G protein-coupled receptors (GPCR) constitute one of the largest family of transmembrane proteins that have been implicated in a multitude of diseases, including cancer and diabetes, and have been an important target in ...