Now showing items 1211-1219 of 1219
Physical Activity and Psychological Well-Being in Older Adults
(2020)
A growing body of research suggests that physical activity (PA) is positively associated with psychological well-being in various populations. However, previous studies have predominantly focused on the preventive or ...
Perivascular Niche and Self-renewal of Dental Pulp Stem Cells
(2020)
Interactions with the microenvironment modulate the fate of stem cells in perivascular niches in tissues (e.g. bone) and organs (e.g. liver). However, the functional relevance of the molecular crosstalk between endothelial ...
The Treatment of Volumetric Muscle Loss in a Clinically Relevant Large Animal Model
(2020)
Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle comprising 20-30% or more of the muscle volume. By definition, VML exceeds the muscle’s capacity for self-repair and results in persistent ...
Integration of Genomic and Epidemiologic Data to Detect Hospital Transmission of Carbapenem-resistant Enterobacteriaceae
(2020)
Carbapenem-resistant Enterobacteriaceae (CRE) are multi-drug resistant organisms (MDROs) that are resistant to nearly all antibiotics and are estimated to be responsible for 8,500 infections and 1,100 deaths in the U.S. ...
Three Enquiries Concerning Hospital-Physician Vertical Integration
(2020)
Hospitals and physicians in the United States increasingly work together under common ownership. Over the past decade, physicians have gravitated toward employment at hospital-owned facilities and hospitals have acquired ...
Use and Evaluation of Statistical Methods for Personalized Medicine in Oncology
(2020)
The goal of personalized medicine is to give the right treatment to the right patient at the right dose using all we know about the patient. With the increasing availability of biomarkers and prediction models, there is ...
Voltage-Gated Sodium Channel B1 Subunit Processing by BACE1 and y-Secretase: Regulatory Mechanisms and Downstream Signaling
(2020)
Voltage-gated sodium channels (VGSCs) are heterotrimeric proteins comprised of one pore-forming, alpha subunit and two non-pore forming, beta subunits. Variants in SCN1B, the gene which encodes VGSC beta1 subunits, are ...
Cellular Mechanisms and Immunological Contexts of Lysosomal Damage Protection in Macrophages
(2020)
As professional phagocytes, macrophages are susceptible to endolysosomal membrane damage inflicted by the pathogens and noxious particles they ingest. Whether macrophages have mechanisms for limiting such damage is a ...
Health Equity Promotion, Measurement, and Evaluation in Community-Based Participatory Research Partnerships
(2020)
Community-based participatory research (CBPR) approaches present meaningful opportunities to promote equity within communities facing social disadvantage. Through empowerment, co-learning, and capacity-building strategies, ...