Now showing items 81-90 of 235
Phase I Clinical Trial of 5-Fluoro-Pyrimidinone (5FP), an Oral Prodrug of 5-Fluorouracil (5FU)
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-02)
Purpose: 5-Fluoro-Pyrimidinone (5FP)is an oral pro-drug of 5-Fluorouracil(5FU), and is converted to 5FU by hepaticaldehyde oxidase. Preclinically, 5FPdemonstrated anti-tumor activity againstcolon 38 and P 388 leukemia ...
In Vitro Selection Using Modified or Unnatural Nucleotides
(Wiley Periodicals, Inc.University of Texas, 2001-12)
The use of modified nucleotides in an RNA or DNA pool to be used for in vitro selection offers many potential advantages, such as the increased stability of the selected nucleic acid against nuclease degradation. This unit ...
Overview of Purification and Analysis of Synthetic Nucleic Acids
(Applied BiosystemsWiley Periodicals, Inc., 2000-07)
Synthetic nucleic acids are produced routinely for a wide variety of applications, including biological and chemical research, and diagnostic or therapeutic applications. To ensure an adequate level of quality and purity, ...
Synthesis of 5′‐O‐Phosphoramidites with a Photolabile 3′‐O‐Protecting Group
(Wiley Periodicals, Inc., 2004-06)
This unit describes the chemical synthesis of phosphoramidite building blocks that carry a protecting group at the 3′ position. These inversely oriented synthons expose a 2‐(2‐nitrophenyl)propoxycarbonyl (NPPOC) group as ...
Oligodeoxyribonucleotide Analogs Functionalized with Phosphonoacetate and Thiophosphonoacetate Diesters
(Humana PressWiley Periodicals, Inc., 2004-09)
Oligodeoxyribonucleotides with phosphonoacetate or thiophosphonoacetate internucleotide linkages can be made in high yield by solid‐phase synthesis and possess many advantages. They are highly stable to nucleases, ...
Theoretical Principles of In Vitro Selection Using Combinatorial Nucleic Acid Libraries
(Wiley Periodicals, Inc., 2000-02)
A new paradigm for drug discovery and biological research has developed from technologies that integrate combinatorial chemistry with rounds of selection and amplification, a technique called in vitro selection or systematic ...
Preparation of Gold Nanoparticle–DNA Conjugates
(Wiley Periodicals, Inc., 2002-06)
This unit describes the preparation of conjugates between nanometer‐scale gold particles and synthetic oligonucleotides. Oligonucleotide‐functionalized gold nanoparticles are finding increased use in both the construction ...