Now showing items 841-850 of 898
Ultrafast Microfluidic Immunoassays Towards Real-time Intervention of Cytokine Storms
(2020)
Biomarker-guided precision medicine holds great promise to provide personalized therapy with a good understanding of the molecular or cellular data of an individual patient. However, implementing this approach in critical ...
Biochemical Studies of Polyketide Beta-Branching and Polyketide Synthase Module Architecture
(2017)
Natural products are bioactive molecules produced across the tree of life and have been used medicinally by humans for millennia. Isolation and characterization of these molecules reveals an incredible diversity of ...
Synthesis and Structure-Activity Relationships of Novel Direct Thrombin Inhibitors based on Pentapeptide FM 19.
(2012)
The serine protease thrombin is the main clotting enzyme in the hemostatic system, in addition to being an effective platelet activator. Modulation of the actions of thrombin can be used as a mechanism to treat myocardial ...
Structural and Functional Characterization of the Human Enzyme Nocturnin
(2019)
The circadian protein Nocturnin (NOCT) belongs to the exonuclease, endonuclease and phosphatase (EEP) superfamily and is most similar to the CCR4-class of deadenylases that degrade the poly-adenosine poly(A) tails of mRNAs. ...
Kinetic Analysis of Human DNA Ligase III
(2019)
DNA ligases catalyze the final step in DNA replication, repair and recombination pathways using a conserved three-step mechanism to generate a single phosphodiester bond. Humans have three LIG genes that encode the DNA ...
Identification of the Mechanisms of mRNA Regulation by PUF Proteins.
(2013)
PUF proteins are conserved RNA-binding proteins that regulate mRNAs through sequence-specific binding. PUFs play integral roles in important biological processes including: development, fertility, and synaptic plasticity. ...
The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.
(2013)
Opioids are widely used in the treatment of pain; however, the development of tolerance and dependence limit clinical use. The co-administration of a µ opioid receptor (MOR) agonist with a δ opioid receptor (DOR) agonist ...
Comparative Investigation of Key Biosynthetic Transformations in Fungal Indole Alkaloid Natural Product Pathways.
(2015)
My dissertational research has focused on the elucidation of three key biosynthetic steps involved in the formation of fungal indole alkaloid natural products. Beginning with the comparative analysis of four assembled ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
Epigenetic and Transcriptional Regulation of Self Renewal in Acute Myeloid Leukemia
(2019)
Acute myeloid leukemia (AML) is diagnosed in >20,000 people/year in the United States alone and is associated with a poor prognosis. AML arises due to altered transcriptional programs resulting from mutations and chromosomal ...