Now showing items 861-870 of 897
The 70-kDa Heat Shock Protein (Hsp70) Chaperone System: Linking ATP Turnover and Complex Formation To Protein Homeostasis.
(2014)
The 70-kDa heat shock protein (Hsp70) is a molecular chaperone that binds unfolded proteins and directs them towards a number of divergent pathways, including folding, trafficking, and degradation. This delicate balance ...
Development and Discovery of Novel Inhibitors of Mycobacterium tuberculosis RNA Polymerase for the Treatment of Tuberculosis
(2022)
Tuberculosis (TB) is an infectious pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). It is the leading cause of death from a single bacterial pathogen and second, only to COVID-19, as the deadliest ...
Mass Spectrometry Based Techniques for In Vivo Neurochemical Monitoring.
(2012)
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. Therefore, the measurement of neurochemical dynamics in live behaving animals’ brain is of crucial importance for the fundamental ...
How a Novel Zinc Finger Domain Improves Target Gene Selection by TCF in WNT/ß-Catenin Signaling.
(2014)
The Wnt/beta-catenin pathway is a highly conserved signaling pathway that plays an important role in metazoan development. T-cell factors (TCF) are transcription factors that regulate the transcription of many Wnt target ...
Structural and Biochemical Mechanisms of MLL1 Activation on Chromatin
(2022)
Transcription is a critical process by which cells regulate temporal and spatial expression of genes. In eukaryotes, histone H3 lysine 4 methylation by the MLL/SET1 family histone methyltransferases is enriched at transcription ...
Thermodynamic and Mathematical Relationships for Predicting Cocrystal Stability and Controlling Dissolution - Supersaturation - Precipitation Behavior
(2020)
Although pharmaceutical cocrystals have emerged as a useful strategy for enhancing the solubility, dissolution, and oral bioavailability of poorly water-soluble drugs, their development has thus far been marked by a lack ...
Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.
(2013)
Damm et al. utilized a multiple protein structure (MPS)-based method and discovery an allosteric site of HIV-1 protease (HIV-1p) that had not been described before. Based on this new site, a MPS-based pharmacophore model ...
Chemical Modulation of Phospho-Signaling Pathways Involved in Cancer.
(2015)
Advancements in our understanding of the molecular causes of cancer have led to the therapeutic targeting of key enzymes involved in cell growth. Kinase inhibitors have been the most successful forms of such targeted therapy ...
Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation
(2019)
Epitope density appears to be a critical factor in pathogens that can elicit effective immune responses. All the viruses that have efficacious FDA-approved target vaccines have high surface densities of antigens. HIV, on ...
Bacterial Cytochrome P450-Mediated Biosynthesis of Non-Symmetrical Diketopiperazine Dimers: Discovery, Catalysis, and Structure
(2019)
The simplest cyclic peptide is composed of two amino acids and forms a 2,5- diketopiperazine (DKP). Diketopiperazine containing natural products can be found from eukaryotic, fungal, and bacterial sources and are present ...