Now showing items 881-890 of 897
Enzyme Aging: Structural Insights from NTE and Patatin.
(2009)
Neuropathy target esterase (NTE) is an integral membrane protein whose covalent modification by organophosphorus compounds (OPs) results in a delayed axonopathy (called OP-induced delayed neuropathy (OPIDN)) whose mechanisms ...
Expanding the Set of Known Substrates of Nuclear RNase P.
(2007)
Ribonuclease P (RNase P) is an essential endonuclease found in all living organisms and is responsible for the removal of the 5’ leader sequence from precursor tRNAs (pre-tRNAs). In bacteria, RNase P is known to process ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Roles of the Unfolded Protein Response in Cultured Cells and Transgenic Murine Models.
(2007)
When protein folding in the endoplasmic reticulum(ER) is disrupted by alterations in homeostasis in the ER lumen, eukaryotic cells activate a series of signal transduction cascades that are collectively termed the Unfolded ...
The Role of Sulfenic Acid Modification in the Regulation of the Cardiovascular Voltage-Gated Potassium Channel, Kv1.5.
(2011)
Atrial fibrillation, the most common cardiac arrhythmia in the United States, is a significant cause of morbidity and mortality. Environmental exposures such as cigarette smoking, as well as pre-existing cardiovascular ...
Regulation of Bone Formation and Pathology by Local Actions of Leptin in the Bone Marrow.
(2011)
Site-specific adipose content of the bone marrow has been noted since the inclusion
of meat into the hominid diet, evidenced by marrow removal from ungulate limb
bones, 2.6 million years ago. Association between marrow fat ...
Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases.
(2011)
Of the approximately 100 tRNA modifications that have been identified thus far, queuine (Q, 7-((4, 5-cis-dihydroxy-2-cyclopenten-1-yl) amino) methyl-7-deazaguanine) is one of the most complicated. Although its physiological ...
The Rift Valley Fever Virus Replicative Cycle.
(2010)
The Rift Valley fever virus (RVFV) is responsible for numerous, explosive epizootics throughout Africa and the Arabian Peninsula. The virus causes disease predominantly in humans and livestock, with sheep and cattle being ...
Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation.
(2012)
In diseases such as lupus or graft-versus-host disease (GVHD), lymphocytes react against self- or allo-antigen and mediate tissue damage. Current treatments for such diseases rely on non-specific immunosuppression and ...
Biochemical and Structural Analyses of Budding Yeast Telomere Associated CST Complex
(2012)
Telomeres are specialized protein-DNA complexes that compose the natural termini of linear chromosomes. Telomeres prevent chromosome ends from deleterious degradation and fusion events and ensure the complete replication ...