Now showing items 11-20 of 30
Glycoprotein analysis using protein microarrays and mass spectrometry
(Wiley Subscription Services, Inc., A Wiley Company, 2010-09)
Protein glycosylation plays an important role in a multitude of biological processes such as cell–cell recognition, growth, differentiation, and cell death. It has been shown that specific glycosylation changes are key in ...
Raman spectroscopy monitoring of the cellular activities of a tissue-engineered ex vivo produced oral mucosal equivalent
(John Wiley & Sons, Ltd., 2011-02)
To ensure quality control and assurance in tissue engineering, noninvasive, real-time and aseptic evaluation of cell-based devices is required before product release. In this study, Raman spectroscopy was applied to monitor ...
Bone quality assessment of osteogenic cell cultures by Raman microscopy
(Humana PressWiley Periodicals, Inc., 2019-03)
The use of autologous stem/progenitor cells represents a promising approach to the repair of craniofacial bone defects. The calvarium is recognized as a viable source of stem/progenitor cells that can be transplanted in ...
The Role of Topological Constraints in RNA Tertiary Folding and Dynamics.
(2014)
Functional RNA molecules must fold into highly complex three-dimensional (3D) structures and undergo precise structural dynamics in order to carry out their biological functions. However, the principles that govern RNA 3D ...
Mapping, Tracking and Modeling the Movements of Single Membrane-Bound Transcription Activator Proteins in Live Vibrio cholerae.
(2014)
Cholera has been known since ancient times, yet there is still no cure. Vibrio cholerae bacteria cause cholera by producing cholera toxin. Cholera toxin production is regulated by the protein ToxT, which itself is regulated ...
Ultrafast Hydration Dynamics Near Extended Macromolecular Interfaces
(2019)
Liquid water is arguably the most complex, but interesting chemical, enabling development and sustenance of life. The tetrahedral geometry of the water molecule allows the formation of a dense network of hydrogen bonds ...
A Tale of Two RNAs: Single Molecule Investigation of the Conformation, Dynamics and Ligand Binding to the PreQ1 and T-box Riboswitches.
(2014)
Riboswitches are structured mRNA domains that can bind cellular metabolites and control gene expression of downstream genes mainly via transcription attenuation or inhibition of translation initiation. Although structures ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Structural Dynamics of the Hepatitis Delta Virus and Hairpin Ribozymes: Implications for Function.
(2014)
Small catalytic RNAs (ribozymes) are a class of RNAs less than 200 nucleotides in length, which are able to catalyze both cleavage and subsequent re-ligation of their own phosphodiester backbones. Cleavage results in ...
Observations of Coherence in Bacterial Reaction Centers Using Two-Dimensional Electronic Spectroscopy
(2018)
Photosynthesis is the process by which plants and photosynthetic bacteria convert absorbed sunlight into usable chemical energy. In the first steps of photosynthesis, light energy absorbed by molecules embedded in ...