Now showing items 2061-2070 of 2093
Structures, Dynamics, and Ribozymes: An Investigation of RNA Structural Dynamics with the Hepatitis Delta Virus and Hairpin Ribozymes.
(2014)
The function of catalytic ribonucleic acid (RNA), or ribozymes, depends on the structural dynamics of the molecule. Although the main function of RNA was once thought to be mainly in the production of proteins, it is now ...
The Function of the ASH1L Histone Methyltransferase in Cancer: A Chemical Biology Approach
(2018)
ASH1L (absent, small, or homeotic-like 1) is a histone lysine methyltransferase (KMTase) that is overexpressed in cancer and activates oncogenic HOX genes. Small molecule inhibitors of ASH1L would be invaluable tools to ...
Understanding Pre-mRNA Dynamics in Single Spliceosome Complexes.
(2013)
The spliceosome is a large RNA-protein complex that catalyzes pre-mRNA splicing by removing sequences called introns and joining of the remaining sequences, called exons, to produce a mature mRNA. Despite over a quarter ...
Interactions Between Fluorescent Molecules and Plasmonic Nanoparticles: A Super-Resolution Study
(2017)
Single-molecule super-resolution imaging techniques play an increasingly important role in studying complex fine structures, dynamics and interactions in nanoscale confined spaces. The resolution of this technique can be ...
Development and Discovery of Novel Inhibitors of Mycobacterium tuberculosis RNA Polymerase for the Treatment of Tuberculosis
(2022)
Tuberculosis (TB) is an infectious pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). It is the leading cause of death from a single bacterial pathogen and second, only to COVID-19, as the deadliest ...
Mass Spectrometry Based Techniques for In Vivo Neurochemical Monitoring.
(2012)
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. Therefore, the measurement of neurochemical dynamics in live behaving animals’ brain is of crucial importance for the fundamental ...
Molecular Recognition of Inhibitors, Metal Ions and Substrates by Ribonuclease P.
(2013)
Ribonuclease P (RNase P) is a divalent metal ion-dependent endonuclease that catalyzes cleavage of the 5’ leader of precursor transfer RNA (pre-tRNA), an essential tRNA processing step in all domains of life. Bacterial ...
Investigation of the Formation of Z-DNA and Other Non-Canonical DNA Conformations Using a Combined Spectroscopic and Biochemical Approach
(2012)
Genomic sequences of DNA not only code for proteins, but also unique structural conformations encompassing a wide variety of helical and base-pairing geometries. Formation of these sequence-specific conformations is driven ...
Thermodynamic and Mathematical Relationships for Predicting Cocrystal Stability and Controlling Dissolution - Supersaturation - Precipitation Behavior
(2020)
Although pharmaceutical cocrystals have emerged as a useful strategy for enhancing the solubility, dissolution, and oral bioavailability of poorly water-soluble drugs, their development has thus far been marked by a lack ...
Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.
(2013)
Damm et al. utilized a multiple protein structure (MPS)-based method and discovery an allosteric site of HIV-1 protease (HIV-1p) that had not been described before. Based on this new site, a MPS-based pharmacophore model ...