Now showing items 2071-2080 of 2090
Biocatalytic Oxidative Dearomatization and Applications in Chemoenzymatic Total Synthesis
(2020)
Natural products, compounds synthesized by all kingdoms of life, offer a wealth of structural diversity, giving rise to an array of biological activities. For centuries chemists looked to nature for the discovery of new ...
Chemical Modulation of Phospho-Signaling Pathways Involved in Cancer.
(2015)
Advancements in our understanding of the molecular causes of cancer have led to the therapeutic targeting of key enzymes involved in cell growth. Kinase inhibitors have been the most successful forms of such targeted therapy ...
Mechanistic and Structural Insights into the Chemical Modulation of Amyloid Aggregation
(2016)
The aggregation of amyloid-beta (Abeta) is implicated in the etiology of Alzheimer’s disease (AD). Aggregation in vivo permits interactions with transition metal ions and lipids of the cell membrane. Abeta-metal interactions ...
Molecular Interactions between Various Model Cell Membranes and Membrane Active Peptides Studied by Sum Frequency Generation Vibrational Spectroscopy.
(2014)
Since the use of native cell membranes for biophysical studies is difficult, membrane mimetics are often used. However, if the model membrane is too simple, it may not be able to provide physiologically meaningful information. ...
Super-resolution Imaging of DNA Replisome Architecture and Dynamics in Live Bacillus Subtilis
(2018)
DNA replication happens in all living organisms and assures that the genome is accurately copied and maintained. The replisome is the molecular machine in cells that replicates DNA, and this protein assembly includes DNA ...
Specialized Metabolites and Related Biosynthetic Enzymes in Tomato Glandular Trichomes: Defining Biological Functions of Specific Gland Types.
(2011)
Trichomes are tiny appendages that grow out from the surfaces of leaves, stems, flowers, and other above-ground parts of many plants. They contribute to important biological functions such as determent of herbivores, ...
Structural and Dynamic Basis for Assembly of the HIV-1 TAR-Tat Ribonucleoprotein Complex
(2011)
The transactivation response element (TAR), located at the 5' end of the HIV-1 genome, regulates the transcription elongation step of viral RNA. The TAR stem-loop binds the HIV viral transactivator protein (Tat), which ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Characterization of the Amyloidogenic Peptides Amylin and PAP248-286.
(2012)
Many diseases in the aging population are associated with a class of peptide that aggregates to form amyloidogenic fibers through a misfolding from random coil, to cross β-sheet fibrils. Diseases such as Alzheimer’s disease, ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...