Now showing items 51-60 of 212
Optimal designs for two-stage genome-wide association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Genome-wide association (GWA) studies require genotyping hundreds of thousands of markers on thousands of subjects, and are expensive at current genotyping costs. To conserve resources, many GWA studies are adopting a ...
Quantification of cytosolic plasmid DNA degradation using high‐throughput sequencing: implications for gene delivery
(Wiley Periodicals, Inc., 2014-03)
Background Although cytosolic DNA degradation plays an important role in decreasing transgene expression, the plasmid degradation pattern remains largely unexplored. Methods Illumina dye sequencing was employed to ...
Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05)
As part of the Genetic Epidemiology Network of Arteriopathy study, hypertensive non-Hispanic White sibships were screened using 471 single nucleotide polymorphisms (SNPs) to identify genes influencing coronary artery ...
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2009-09)
Genome-wide association studies are helping to dissect the etiology of complex diseases. Although case-control association tests are generally more powerful than family-based association tests, population stratification ...
Recommended Joint and Meta‐Analysis Strategies for Case‐Control Association Testing of Single Low‐Count Variants
(Chapman and HallWiley Periodicals, Inc., 2013-09)
In genome‐wide association studies of binary traits, investigators typically use logistic regression to test common variants for disease association within studies, and combine association results across studies using ...
Haplotype association analysis for late onset diseases using nuclear family data
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
In haplotype-based association studies for late onset diseases, one attractive design is to use available unaffected spouses as controls (Valle et al. [1998] Diab. Care 21:949–958). Given cases and spouses only, the standard ...
Smoking and Genetic Risk Variation Across Populations of European, Asian, and African American Ancestry—A Meta‐Analysis of Chromosome 15q25
(Wiley Periodicals, Inc., 2012-07)
Identification of FAK substrate peptides via colorimetric screening of a one‐bead one‐peptide combinatorial library
(Wiley Periodicals, Inc., 2015-04)
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...