Now showing items 81-90 of 212
Statistical Analysis of Multiplex Brain Gene Expression Images
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-10)
Analysis of variance (ANOVA) was employed to investigate 9,000 gene expression patterns from brains of both normal mice and mice with a pharmacological model of Parkinson's disease (PD). The data set was obtained using ...
On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins
(BIPM, SevresWiley Periodicals, Inc., 2019-03)
Since the early 2000s, numerous computational tools have been created and used to predict intrinsic disorder in proteins. At present, the output from these algorithms is difficult to interpret in the absence of standards ...
A scan statistic for identifying chromosomal patterns of SNP association
(Wiley Subscription Services, Inc., A Wiley Company, 2006-11)
We have developed a single nucleotide polymorphism (SNP) association scan statistic that takes into account the complex distribution of the human genome variation in the identification of chromosomal regions with significant ...
Effect of carbon starvation on toluene degradation activity by toluene monooxygenase-expressing bacteria
(Kluwer Academic Publishers; Springer Science+Business Medaia Inc., 2006-02-14)
Subsurface bacteria commonly exist in a starvation state with only periodic exposure to utilizable sources of carbon and energy. In this study, the effect of carbon starvation on aerobic toluene degradation was quantitatively ...
Importance of Different Types of Prior Knowledge in Selecting Genome‐Wide Findings for Follow‐Up
(Wiley Periodicals, Inc.Jessica Kingsley, 2013-02)
Biological plausibility and other prior information could help select genome‐wide association ( GWA ) findings for further follow‐up, but there is no consensus on which types of knowledge should be considered or how to ...
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
(WILEY-VCH Verlag, 2011-04)
Affinity purification coupled to mass spectrometry (AP-MS) represents a powerful and proven approach for the analysis of protein–protein interactions. However, the detection of true interactions for proteins that are ...
Epigenetic responses following maternal dietary exposure to physiologically relevant levels of bisphenol A
(Wiley Subscription Services, Inc., A Wiley Company, 2012-06)
Animal studies have linked perinatal bisphenol A (BPA) exposure to altered DNA methylation, but little attention is given to analyzing multiple physiologically relevant doses. Utilizing the viable yellow agouti ( A vy ...
Dose‐dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ‐secretase inhibitor
(WILEY‐VCH Verlag, 2011-12)
Notch signaling has been demonstrated to have a central role in glioblastoma (GBM) cancer stem cells (CSCs) and we have demonstrated recently that Notch pathway blockade by γ‐secretase inhibitor (GSI) depletes GBM CSCs and ...
How microbial proteomics got started
(WILEY‐VCH Verlag, 2011-08)
Publication in 1975 by Patrick O'Farrell of a procedure to separate the proteins of Escherichia coli in a two‐dimensional array on polyacrylamide gels marked the birth of the field now called proteomics. Although O'Farrell's ...
Mercury biomarkers and DNA methylation among michigan dental professionals
(Wiley Periodicals, Inc., 2013-04)