Now showing items 251-260 of 260
Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo
(Wiley Periodicals, Inc., 2020-01)
Metastases are preceded by stochastic formation of a hospitable microenvironment known as the premetastatic niche, which has been difficult to study. Herein, we employ implantable polycaprolactone scaffolds as an engineered ...
CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts
(Wiley Periodicals, Inc., 2021-04)
This study elucidates the mechanism of CCL25 and CCR9 in rheumatoid arthritis (RA). RA synovial fluid (SF) expresses elevated levels of CCL25 compared to OA SF and plasma from RA and normal. CCL25 was released into RA SF ...
Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing
(Wiley Periodicals, Inc., 2020-12)
Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that ...
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
(Wiley, 2019-10)
These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid ...
TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response
(WILEY-VCH Verlag, 2007-10)
Type 1 (Th1) granulomas can be studied in mice sensitized with mycobacterium antigens followed by challenge of agarose beads covalently coupled to purified protein derivative. TLR9 is known to play a role in the regulation ...
Investigation of Apoptosis and Metabolism as Mechanisms of Trichloroethylene Toxicity During Pregnancy
(2020)
Trichloroethylene (TCE), an organic solvent with multiple industrial uses, is associated with adverse pregnancy outcomes in epidemiological studies. In timed-pregnant Wistar rats, TCE exposure reduces fetal weight. ...
Mapping Protein-Protein Interactions in Self-Sufficient Cytochrome P450 Enzymes
(2021)
Cytochrome P450 (P450) proteins are heme-containing mixed function oxidase enzymes that play a critical role in the metabolism of drugs and toxicants. For P450 enzyme catalysis, a flavin-containing reductase must shuttle ...
The Oxidative Modification of Mitochondrial Proteins in 1,3-Dinitrobenzene Induced Neurotoxicity.
(2009)
1,3-DNB has widespread use in industry and the military as a chemical intermediate in the development of various plastics, dyes, and explosives. As a result, the production and improper disposal of various DNB-containing ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
The Role of Sulfenic Acid Modification in the Regulation of the Cardiovascular Voltage-Gated Potassium Channel, Kv1.5.
(2011)
Atrial fibrillation, the most common cardiac arrhythmia in the United States, is a significant cause of morbidity and mortality. Environmental exposures such as cigarette smoking, as well as pre-existing cardiovascular ...