Now showing items 11-20 of 786
Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-04)
Bronchogenic carcinoma is the leading cause of malignancy-related mortality in the United States, with an overall 5-year survival rate of less than 15%. This aggressive behavior reflects, among other traits, the capacity ...
2-(3-Pyrrolin-1-yl)-1,4-naphthoquinones: Photoactivated Alkylating Agents
(WILEY-VCH Verlag, 2008-09)
The preparation of 2-(3-pyrrolin-1-yl)-1,4-naphthoquinones and a study of their use as photoactivated alkylating agents is reported. The title compounds were easily synthesized by conjugate addition of the corresponding ...
Omics‐Based Systems Vaccinology for Vaccine Target Identification
(Wiley Periodicals, Inc., 2012-12)
Preclinical Research Omics technologies include genomics, transcriptomics, proteomics, metabolomics, and immunomics. These technologies have been used in vaccine research, which can be summarized using the term ...
Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known
(Wiley Subscription Services, Inc., A Wiley Company, 2006-07)
The ratio of male and female genetic map distances varies dramatically across the human genome. Despite these sex differences in genetic map distances, most multipoint linkage analyses use sex-averaged genetic maps. We ...
Glycoproteomic markers of hepatocellular carcinoma‐mass spectrometry based approaches
(Wiley Periodicals, Inc., 2019-05)
Haplotype variation and genotype imputation in African populations
(Wiley Subscription Services, Inc., A Wiley Company, 2011-12)
Sub‐Saharan Africa has been identified as the part of the world with the greatest human genetic diversity. This high level of diversity causes difficulties for genome‐wide association (GWA) studies in African populations—for ...
Quantifying Prefibrillar Amyloids in vitro by Using a “Thioflavin-Like” Spectroscopic Method
(WILEY-VCH Verlag, 2010-09-03)
In Alzheimer's disease (AD) and other neurodegenerative disorders, proteins accumulate into ordered aggregates, called amyloids. Recent evidence suggests that these structures include both large, insoluble fibrils and ...
Engineering Specific Cross‐Links in Nucleic Acids Using Glycol Linkers
(Wiley Periodicals, Inc., 2000-02)
One of the most convenient methods for generating oligonucleotides possessing intra‐ or interstrand cross‐links is through incorporation of oligoethylene glycol bridges by solid‐phase synthesis. The reagents are commercially ...