Now showing items 2021-2030 of 2090
Selectivity Mechanisms Employed by Flavin-Dependent Monooxygenases
(2021)
Nature is an incredible source of inspiration for the discovery and subsequent development of new bioactive compounds. Unfortunately, the synthesis of these molecules is often prohibitively complex, requiring the installation ...
Probing the Chemical Space for Non-Promiscuous Nucleic Acid Binders
(2023)
Our understanding of DNA, RNA & RNA motifs has catapulted in the last few decades, and as we have begun to better understand their role in disease, we’ve seen an influx of therapeutic tools & technologies that are actively ...
Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids.
(2013)
Transient and moderate affinity protein-protein interactions (PPIs) play a critical role in the regulation of essential cellular processes including protein folding, ubiquitylation, and transcription. A number of disease ...
Activation of Protein Ubiquitination by the Antiviral Enzyme, Viperin
(2021)
Viperin (Virus Inhibitory Protein; Endoplasmic Reticulum-associated, Interferon iNducible) is an interferon-stimulated gene that is upregulated as a part of the innate immune response to viral infection. It has been shown ...
Regulation of Activity and Selectivity of Histone Deacetylases
(2021)
Acetylation is an important post-translational modification (PTM). Lysine acetylation is a reversible PTM, where deacetylation is catalyzed by histone deacetylases (HDACs). Histone deacetylase function is crucial for a ...
Structural and Biochemical Insights into Methylation Site and State Specificity of JMJD2 Lysine Demethylases.
(2012)
The human JMJD2/KDM4 family of histone lysine demethylases comprises four homologs: JMJD2A, JMJD2B, JMJD2C and JMJD2D. These enzymes have been implicated in a number of biological processes such as transcriptional activation, ...
A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides
(2018)
Cap-dependent protein translation (CdT) is dysregulated in many types of cancer and leads to overexpression of oncogenes promoting angiogenesis, evasion of apoptosis, and cell proliferation. The protein-protein interactions ...
Development of Modular, Droplet Microfluidic Workflows to Investigate Cellular Heterogeneity
(2023)
Cells exist in unique contexts within a population, but miniscule differences in their environment, epigenome, and cell cycle produce an assortment of observable characteristics in cells. Conventional cellular analysis ...
Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase
(2019)
An instrumental aspect of cancer progression is the acquired deregulation of the cellular processes that regulate growth and proliferation. Most of these processes are, at some level, controlled by a kinase-catalyzed change ...
Decoding the Bio-Assembly of Hapalindole-Type Alkaloids from Cyanobacteria for Drug Discovery
(2017)
Biosynthetic exploration of natural products provides a promising opportunity to produce novel bioactive molecules for drug development. Hapalindole-type alkaloids are a large group of secondary metabolites isolated from ...