Now showing items 11-17 of 17
Multiscale Modeling of Tuberculosis Disease and Treatment to Optimize Antibiotic Regimens
(2020)
Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at ...
Fabrication of Non-Spherical Biodegradable Particles for Drug Delivery Applications and Studying the Impact of Shape on the Efficacy of Particulate Carriers
(2020)
Biodegradable particles are used to specifically deliver drugs to diseased sites to increase their efficacy and minimize their side effects. Until now, most of the drug delivery platforms have been spherical in their shape ...
Continuous Microfluidic Viscometers for Biochemical and Diagnostic Analysis
(2017)
Microfluidic technologies have advanced rapidly over the past two decades. Numerous microfluidic devices to assess different biomarkers have been reported, yet very few address physical properties, such as viscosities, of ...
Isolation and Characterization of Circulating Biomarkers to Predict Patient Outcomes in Late-Stage Non-Small Cell Lung Cancer
(2021)
This work hypothesizes that the molecular characterization of extracellular vesicles (EVs) and circulating tumor cells (CTCs), biomarkers found in peripheral blood draws, can be used to monitor, and predict, treatment ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Engineering the Quantitative PCR Assay for Decreased Cost and Complexity.
(2011)
The quantitative polymerase chain reaction (qPCR) is an assay of target nucleic acid concentration. Clinical applications of quantitative PCR include measurement of HIV viral load, measurement of bacterial infection, and ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...