Now showing items 161-165 of 165
Probing Nucleic Acid Structure with Nickel‐ and Cobalt‐Based Reagents
(Kluwer Academic PublishersWiley Periodicals, Inc., 2000-02)
The use of nickel and cobalt reagents is presented for characterizing the solvent exposure of guanine residues in DNA and RNA. These reagents promote guanine oxidation in the presence of a peracid such as monopersulfate, ...
Engineering Disulfide Cross‐Links in RNA Via Air Oxidation
(Oxford University PressWiley Periodicals, Inc., 2000-02)
This unit presents protocols for the synthesis of alkylthiol‐modified ribonucleosides, their incorporation into synthetic RNA, and the formation of intramolecular disulfide bonds in RNA by air oxidation. The disulfide bonds ...
Introduction to the Synthesis and Purification of Oligonucleotides
(Applied BiosystemsWiley Periodicals, Inc., 2000-02)
Modern nucleic acid synthesizers utilize phosphite triester chemistries that employ stable phosphoramidite monomers to build a growing polymer. These robust reactions allow easy generation of specific oligodeoxyribo‐ and ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Chemometric Methods for the Determination of Volatile Organic Compounds with Microsensor Arrays.
(2008)
This research addresses critical chemometric modeling and data analysis functions needed to guide the design and implementation of novel meso-scale and micro-scale instrumentation that incorporates chromatographic separation ...