Now showing items 341-350 of 382
Raulin award lecture: Wilson's disease therapy with zinc and tetrathiomolybdate
(John Wiley & Sons, Inc., 2000)
Zinc and tetrathiomolybdate, effective, nontoxic drugs, have now been added to the treatment of most phases of Wilson's disease. Zinc is used for maintenance as well as treating presymptomatic, pregnant, and pediatric ...
Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme
(Wiley Subscription Services, Inc., A Wiley Company, 2007-04-05)
The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil ...
Statistical mechanics of protein folding by cluster distance geometry
(Wiley Subscription Services, Inc., A Wiley Company, 2004-10-15)
This is our second type of model for protein folding where the configurational parameters and the effective potential energy function are chosen in such a way that all conformations are described and the canonical partition ...
Innentitelbild: Multicompartmental Microcylinders (Angew. Chem. 25/2009)
(WILEY-VCH Verlag, 2009-06-08)
Mikrozylinder mit mehreren Kompartimenten lassen sich mit einer Kombination aus elektrohydrodynamischem Spinnen und Mikroabtrennen herstellen, wie J. Lahann et 14al. in der Zuschrift auf S. 144659 14ff. beschreiben. Die ...
Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribo‐ and Oligoribonucleotides According to the H‐Phosphonate Method
(Wiley Periodicals, Inc.Humana Press, 2000-02)
Oligonucleotides can be synthesized by condensing a protected nucleoside H‐phosphonate monoester with a second nucleoside in the presence of a coupling agent to produce a dinucleoside H‐phosphonate diester. This can then ...
Analysis and Purification of Synthetic Nucleic Acids Using HPLC
(Wiley Periodicals, Inc.Stockton Press, 2000-07)
HPLC is a powerful and popular method for analyzing and purifying biomolecules. Reversed‐phase HPLC allows a high‐capacity method for purification, and uses volatile buffer systems that simplify product recovery. Anion‐exchange ...
A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A 2 with ceramide transacylase activity
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-01)
A series of inhibitors of glucosylceramide synthesis, the PDMP based family of compounds, has been developed as a tool for the study of sphingolipid biochemistry and biology. During the course of developing more active ...
Amperometric Nitrosothiol Sensor Using Immobilized Organoditelluride Species as Selective Catalytic Layer
(WILEY-VCH Verlag, 2008-02)
A new amperometric sensor capable of responding to various biological S -nitrosothiol species (RSNOs) is described. The sensor is prepared using an organoditelluride-tethered poly(allyamine hydrochloride) (PAH) polymer ...
The 4â Methylthioâ 1â Butyl Group for Phosphate/Thiophosphate Protection in Oligodeoxyribonucleotide Synthesis
(Wiley Periodicals, Inc., 2004-12)
The detailed preparation of deoxyribonucleoside phosphoramidites functionalized with a 4â methylthioâ 1â butyl group for P(III) protection is described, along with the incorporation of these phosphoramidites into DNA ...
Commentary: Landmark articles on copper in the field of human health
(John Wiley & Sons, Inc., 2001)
No abstract.