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Adrenal proteins bound by a reactive intermediate of mitotane
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-02)
Purpose : Mitotane ( o,p ′-DDD), is the only adrenolytic agent available for the treatment of adrenocortical carcinoma. Previous studies have shown that mitotane covalently binds to adrenal proteins following its metabolism ...