Now showing items 51-60 of 373
Augmentation of hepatic doxorubicin extraction with extracorporeal filtration avoids the dose-dependent, nonlinear increase in AUC observed with systemic administration
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-12)
Purpose : Regional therapy of primary or metastatic liver cancer with low hepatic extraction ratio drugs such as doxorubicin is constrained by development of systemic toxicity. To examine the effect of augmentation of ...
Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography
(Elsevier, 1994-04-29)
The direct optical resolution of the vesicular acetylcholine uptake inhibitors vesamicol and benzovesamicol and nine benzovesamicol analogues were performed by HPLC on a commercially available cellulose tris(3,5-dimethylphenyl ...
Iodine-promoted decomposition of 1-aryl-3,3-dialkyltriazenes: A mild method for the synthesis of aryl iodides
(Elsevier, 1994-08-01)
Iodine promoted decomposition of 1-aryl-3,3-dialkyltriazenes in organic solvents is shown to give high yields of the corresponding aryl iodides under extremely mild conditions. The presence of iodine greatly accelerates ...
Modulation of opioid signal transduction in SH-SY5Y neural cells by differentiating agents: Concurrent mu receptor upregulation and effector desensitization by phorbol ester
(Elsevier, 1994-02-21)
Long-term exposure of SH-SY5Y human neural cells to retinoic acid (RA) increased the binding of [3H]DAMGO and [3H]DPDPE by up to 3-fold compared to membranes of untreated cells. In contrast, incubation of the cells with ...
Design of molecular architectures for polymeric mesophase formation
(Wiley Periodicals, Inc.Hüthig & Wepf Verlag, 1995-07)
Based on the tendency of low molar mass liquid crystals composed of extended mesogens symmetrically disubstituted with long n ‐alkoxy substituents to exhibit smectic C mesophases, we have proposed that SCLCPs with laterally ...
Expression of Wild-Type and Mutant Rat Liver CTP: Phosphocholine Cytidylyltransferase in a Cytidylyltransferase-Deficient Chinese Hamster Ovary Cell Line
(Elsevier, 1994-05)
The strain 58 Chinese hamster ovary (CHO) mutant defective in CTP:phosphocholine cytidylyltransferase was characterized as an expression system for exogenous cytidylyltransferase. Strain 58 cells express less than 5% of ...
Synthesis and assignments of regioisomeric cyanoimidazole esters
(Elsevier, 1994-02-28)
Regioassignments of ethyl cyanoimidazolecarboxylates have been performed by the nuclear Overhauser effect(NOE) studies on the regioisomeric monocyanoimidazoles obtained by the hydrolysis of the esters followed by ...
Synthesis of (+/-)tylophorine by the intramolecular cycloaddition of an azide with an [omega]-chloroalkene
(Elsevier, 1994)
Cyclization of (Z)-1-(2-chloromethyl)phenyl-5-azidopent-1-ene 10 in benzene at 120[deg]C followed by treatment with sodium borohydride produced 1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline 11 in 71% yield. A similar ...
Thermodynamics of alkali alkanoates X. Heat capacities and thermodynamic properties of lithium methanoate and lithium ethanoate at temperatures from [approximate] 5 K to 580 K
(Elsevier, 1994-12)
Heat capacities of lithium methanoate and ethanoate (CA Registry numbers [556-63-8] and [546-89-4]) have been measured by adiabatic intermittent-heating equilibrium calorimetry from temperatures T near 5 K to 350 K and by ...
Hydrazine adsorption and decomposition on the GaAs(100)-c(8 x 2) surface
(Elsevier, 1994-12-20)
Temperature programmed desorption (TPD), X-ray photoelectron spectroscopy (XPS), and high resolution electron energy loss spectroscopy (HREELS) have been used to study the decomposition mechanism of hydrazine (N2H4) on the ...