Now showing items 91-100 of 100
Dual‐detection approach for a charge variant analysis of monoclonal antibody combination products using imaged capillary isoelectric focusing
(Wiley Periodicals, Inc.Springer Science+Business Media, 2022-09)
The clinical benefits of treatments with a combination of two or more therapeutic monoclonal antibodies (mAbs) have emerged in recent years. Imaged capillary isoelectric focusing is a frequently used technology in the ...
Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.
(2010)
Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary mediator of canonical Wnt ...
(1) The Relationship of Protein Expression and Cell Division, (2) 3D Imaging of Cells Using Digital Holography, and (3) General Chemistry Enrollment at University of Michigan.
(2012)
Chapter 1: We evaluated the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Computational Methods for Characterizing Post-translational and Chemical Modifications Found in Open Searches
(2022)
Post-translational modifications (PTMs) govern many processes within cells and understanding their function is critical to both the basic and biomedical sciences. However, identifying modified peptides, particularly ...
Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase
(2019)
An instrumental aspect of cancer progression is the acquired deregulation of the cellular processes that regulate growth and proliferation. Most of these processes are, at some level, controlled by a kinase-catalyzed change ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...