Now showing items 491-499 of 499
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Chemometric Methods for the Determination of Volatile Organic Compounds with Microsensor Arrays.
(2008)
This research addresses critical chemometric modeling and data analysis functions needed to guide the design and implementation of novel meso-scale and micro-scale instrumentation that incorporates chromatographic separation ...
SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.
(2009)
The calculation of physicochemical and biological properties is essential in order to facilitate modern drug discovery. Chemical spaces dimensionalized by these descriptors have been used to scaffold-hop in order to discover ...
Thermodynamic and Kinetic Parameters that Explain Crystallization and Solubility of Pharmaceutical Cocyrstals.
(2009)
Cocrystals have emerged as a viable alternative to increase the diversity of solid-state drug forms. Literature surrounding cocrystals range from design using crystal engineering principles to evaluating the pharmaceutical ...
Fast Capillary Electrophoresis for the Study of Dopamine in the Central Nervous System.
(2011)
The study of neurochemical events in the central nervous system (CNS) with temporal resolution ranging from seconds to minutes facilitates the evaluation of intercellular communication on times scales that are relevant to ...
A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.
(2011)
Predicting and controlling the systemic and local pharmacokinetics of pulmonary medications in different regions of the lung is critical for optimizing the efficacy and safety of inhaled drugs. Here, a modular, multiscale, ...
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.
(2012)
MLL1 is a histone-3 lysine-4 (H3K4) methyltransferase, which is misregulated in patients with leukemia and linked with tumorigenicity through upregulation of the target genes HoxA9 and Meis-1. Suppressing expression of ...
Transparent and Self-Healing Elastomers for Reconfigurable 3D Materials
(Wiley Periodicals, Inc., 2022-12)
Transparent soft materials are widely used in applications ranging from packaging to flexible displays, wearable devices, and optical lenses. Nevertheless, soft materials are susceptible to mechanical damage, leading to ...