Now showing items 31-40 of 466
Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
(Elsevier, 1984-12)
DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) ...
Strategies for studying opioid peptide regulation at the gene, message and protein levels
(Elsevier, 1984)
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue: pro-opiomelanocortin, pro-enkephalin, and pro-dynorphin. Since each of those opioid peptide systems have been extensively ...
Sensitive high-performance liquid chromatographic assay using 9-fluorenylmethylchloroformate for monitoring controlled-release lidocaine in plasma
(Elsevier, 1989)
A sensitive high-performance liquid chromatographic (HPLC) assay using fluorescence detection for quantifying lidocaine levels in plasma (in the ng/ml range) was developed. This novel HPLC assay has made possible the ...
The heat-stable cytosolic factor that promotes glucocorticoid receptor binding to DNA is neither thioredoxin nor ribonuclease
(Elsevier, 1987-11)
Treatment of rat liver cytosol containing temperature-transformed [3H]dexamethasone-bound receptors at 0[deg]C with the sulfhydryl modifying reagent methyl methanethiosulfonate (MMTS) inhibits the DNA-binding activity of ...
Vascular endothelial cell killing by combinations of membrane-active agents and hydrogen peroxide
(Elsevier, 1989)
Previous studies have demonstrated that a number of membrane-active agents are capable of binding to the surface of polymorphonuclear leukocytes (PMN) resulting in an augmentation of superoxide anion and hydrogen peroxide ...
Carboplatin (CBDCA), iproplatin (CHIP), and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity
(Springer-Verlag, 1987-02)
We compared the acute tubular nephrotoxicity of three platinum compounds in children and adults with solid tumors by monitoring the urinary excretion of alanine aminopeptidase, N -acetyl-β-D-glucosaminidase, and total ...
Kinetic comparisons of amniotic fluid inactive renin and renal renin using synthetic and human renin substrates
(Elsevier, 1986-12)
Inactive renin has been isolated from pooled amniotic fluid and purified ~642-fold. Prior to activation the isolates has ~4% of the activity found after activation. The observation is similar to that reported for inactive ...
Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats
(Elsevier, 1988)
The effects of highly selective mu and delta opioid peptide agonists were determined in two rat models of experimentally-induced convulsions, the flurothyl threshold test and the maximal electroshock test. Intracerebroventricular ...