Now showing items 11-20 of 70
An in vivo and in vitro trial of aclarubicin in metastatic breast cancer: a novel approach to the study of analogs
(Springer-Verlag, 1993-11)
Aclarubicin is an anthracycline antibiotic that differs from doxorubicin in its structure, mechanism of action, and preclinical toxicity profile, especially its reduced cardiotoxicity. We therefore conducted a side-by-side ...
Interaction of viable group a streptococci and hydrogen peroxide in killing of vascular endothelial cells
(Elsevier, 1993-05)
Previous studies have shown that the streptococcal hemolysin, streptolysin S, is capable of interacting with hydrogen peroxide (H2O2) to injure vascular endothelial cells (Free Radic. Biol. Med. 7:369-376; 1989). To extend ...
The synthesis of DL-3,3-Difluoroglutamic acid from a 3-oxoprolinol derivative
(Elsevier, 1993-07-30)
DL-3,3-Difluoroglutamic acid was synthesized from a masked 3-hydroxyprolinol, 6-hydroxy-1-aza-3-oxabicyclo[3.3.0]octan-2-one, in eight steps. The described synthetic route expands the utility of fluoroproline derivatives ...
Assay of human plasma cortisone by liquid chromatography: normal plasma concentrations (between 8 and 10 a.m.) of cortisone and corticosterone
(Elsevier, 1993-04-02)
A high-performance liquid chromatographic method using ultraviolet detection to quantitate human plasma concentrations of cortisone simultaneously with cortisol and corticosterone is described. The method is based on the ...
A Continuous Spectrophotometric and Fluorometric Assay for Protein Tyrosine Phosphatase Using Phosphotyrosine-Containing Peptides
(Elsevier, 1993-05-15)
Two continuous assays for protein tyrosine phosphatases (PTPases) have been developed using phosphotyrosine containing peptide substrates. These assays are based on the marked differences in the spectra of the peptide ...
IGF receptor function and regulation in autocrine human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factor-II (IGF-II) and its receptors (type I and II IGF receptors) are expressed in the nervous system in a tissue and developmentally specific manner. We have previously shown that SH-SY5Y human ...
Lactate Oxidation for the Detection of Mitochondrial Dysfunction in Human Skin Fibroblasts
(Elsevier, 1993-05-01)
To screen fibroblasts for defects in lactate/pyruvate oxidation, cells were grown to confluence in 25-cm2 flasks, rinsed, and incubated in glucose-free media containing 25 [mu]M L-lactate and 0.1 [mu]Ci [D,L-1-14C]lactate. ...
Thermodynamics of divalent-metal fluorides VI. Heat capacity and thermodynamic properties of the fast-ion conductor CaSn2F6 at temperatures from 6 K to 310 K
(Elsevier, 1993-02)
The molar heat capacity Cp. m of calcium hexafluorostannate CaSn2F6 was measured at temperatures T from 6 K to 310 K by adiabatic calorimetry. Reproducible heat capacities were obtained only after cooling the sample twice ...