Now showing items 91-100 of 104
FRACPRED- 2D- PRM: A Fraction Prediction Algorithm- Assisted 2D Liquid Chromatography- Based Parallel Reaction Monitoring- Mass Spectrometry Approach for Measuring Low- Abundance Proteins in Human Plasma
(Wiley Periodicals, Inc., 2020-12)
Multidimensional fractionation- based enrichment methods improve the sensitivity of proteomic analysis for low- abundance proteins. However, a major limitation of conventional multidimensional proteomics is the extensive ...
Dual‐detection approach for a charge variant analysis of monoclonal antibody combination products using imaged capillary isoelectric focusing
(Wiley Periodicals, Inc.Springer Science+Business Media, 2022-09)
The clinical benefits of treatments with a combination of two or more therapeutic monoclonal antibodies (mAbs) have emerged in recent years. Imaged capillary isoelectric focusing is a frequently used technology in the ...
Developing and Application of Statistical Algorithms for High-Demensional Biological Data Analysis
(2012)
Various high-throughput technologies have fueled advances in biomedical research in the last decade. Two typical examples are gene expression and genomic hybridization microarrays that quantify RNA and DNA levels respectively. ...
Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression In Vivo: Addressing the Fragility Phenotype
(2019)
Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there ...
Computational Methods for Characterizing Post-translational and Chemical Modifications Found in Open Searches
(2022)
Post-translational modifications (PTMs) govern many processes within cells and understanding their function is critical to both the basic and biomedical sciences. However, identifying modified peptides, particularly ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Stem Cell-Based Modeling of Early Human Neural Development
(2020)
Neurulation is a key embryonic developmental process that gives rise to the formation of the neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the ...
Multidisciplinary Study of Soft Shape Morphing Systems
(2021)
Nature abounds with examples of shape morphing systems where an entity either gradually grows into a complex 3-D shape pattern or rapidly morphs into a new configuration. Inspired by the shape shifting capabilities of ...
Engineering Platforms for Mimicking Cellular Processes using Cell-Free Expression Systems
(2020)
Bottom-up in vitro reconstitution has provided fundamental insights into the mechanisms of key cellular processes. Traditional reconstitution methods rely on protein purification as the primary means of extracting functional ...
On the Phenotype of White-tailed Deer Antlerogenic Progenitor Cells.
(2013)
Repair of large bone defects is one of the key unmet clinical needs in musculoskeletal medicine. A rare exception to the limits of mammalian regeneration is the deer antler, the only example of complete, repeated organ ...