Now showing items 41-50 of 104
How microbial proteomics got started
(WILEY‐VCH Verlag, 2011-08)
Publication in 1975 by Patrick O'Farrell of a procedure to separate the proteins of Escherichia coli in a two‐dimensional array on polyacrylamide gels marked the birth of the field now called proteomics. Although O'Farrell's ...
Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20
(WILEY-VCH Verlag, 2006-05)
Chronic exercise training elicits adaptations in the heart that improve pump function and confer cardioprotection. To identify molecular mechanisms by which exercise training stimulates this favorable phenotype, a proteomic ...
Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells
(WILEY-VCH Verlag, 2007-08)
The molecular chaperone heat shock protein 90 (Hsp90) affects the function of many oncogenic signaling proteins including nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressed in anaplastic large cell lymphoma (ALCL). ...
Proteomic profiling identifies breast tumor metastasis-associated factors in an isogenic model
(WILEY-VCH Verlag, 2007-01)
A combination of LC and MS was applied to an isogenic breast tumor metastasis model to identify proteins associated with a cellular phenotype. Chromatofocusing followed by nonporous-RP-HPLC/ESI-TOF MS was applied to cell ...
Development of selected reaction monitoring-MS methodology to measure peptide biomarkers in prostate cancer
(WILEY-VCH Verlag, 2010-10)
Prostate cancer is a leading cause of cancer-related death. The current modality of diagnosis, the measurement of serum PSA, not only suffers from lack of specificity, but does not distinguish clinical cases in which current ...
Label‐free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity
(Wiley Periodicals, Inc., 2015-07)
Measurement of dissociation rate of biomolecular complexes using CE
(WILEY-VCH Verlag, 2009-02)
Fluorescence anisotropy (FA), non-equilibrium CE of equilibrium mixtures (NECEEM) and high-speed CE were evaluated for measuring dissociation kinetics of peptide–protein binding systems. Fyn-SH3-SH2, a protein construct ...
Untargeted, spectral libraryâ free analysis of dataâ independent acquisition proteomics data generated using Orbitrap mass spectrometers
(Chapman & Hall/CRCWiley Periodicals, Inc., 2016-08)
Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform
(WILEY-VCH Verlag, 2006-11)
During apoptosis nuclear morphology changes dramatically due to alterations of chromatin architecture and cleavage of structural nuclear proteins. To characterize early events in apoptotic nuclear dismantling we have ...
Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma
(Wiley Periodicals, Inc., 2017-11)
Extensive efforts have been devoted to improve the diagnosis of extrahepatic cholangiocarcinoma (ECCA) due to its silent clinical character and lack of effective diagnostic biomarkers. Specific alterations in N‐glycosylation ...