Now showing items 501-509 of 509
Medical Ultrasound Aberration Correction via Acoustic Droplet Vaporization and Time-Reversal Acoustics.
(2009)
Time-reversal acoustics (TRA) is an alternative to standard focusing approaches in medical ultrasound. TRA records backscattered ultrasound and time-reverses it (Ψ(t) -> Ψ(−t)). Due to the time-reversal invariance of the ...
Automated Natural-Language Processing for Integration and Functional Annotation of Complex Biological Systems.
(2008)
This dissertation discusses the use of automated natural language processing (NLP) for characterization of biomolecular events in signal transduction pathway databases. I also discuss the use of a dynamic map engine for ...
Novel Bioinformatics Approaches for MicroRNA Detection and Target Prediction.
(2009)
MicroRNAs (miRNAs) are regulators of gene expression at the post-transcriptional level. Scientists have not been able to fully unlock their therapeutic potential because their functions and mechanisms of action have not ...
SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.
(2009)
The calculation of physicochemical and biological properties is essential in order to facilitate modern drug discovery. Chemical spaces dimensionalized by these descriptors have been used to scaffold-hop in order to discover ...
Memory, Interference and Depression.
(2010)
This dissertation explores the role of interference in short-term memory and how interference in memory may influence depression. The first chapter tackles whether forgetting in the short-term is due to decay with the ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
Engineering the Quantitative PCR Assay for Decreased Cost and Complexity.
(2011)
The quantitative polymerase chain reaction (qPCR) is an assay of target nucleic acid concentration. Clinical applications of quantitative PCR include measurement of HIV viral load, measurement of bacterial infection, and ...
Transparent and Self-Healing Elastomers for Reconfigurable 3D Materials
(Wiley Periodicals, Inc., 2022-12)
Transparent soft materials are widely used in applications ranging from packaging to flexible displays, wearable devices, and optical lenses. Nevertheless, soft materials are susceptible to mechanical damage, leading to ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...