Now showing items 51-60 of 509
Site‐Specific Fluorescent Labeling of Large RNAs with Pyrene
(Oxford University PressWiley Periodicals, Inc., 2004-12)
Pyrene is a useful chromophore for monitoring the tertiary structure and folding of large RNAs. This unit describes the general preparation of a large RNA (>80 nucleotides in length) that has been site‐specifically modified ...
Preparation of 2′‐O‐[(Triisopropylsilyl)oxy]methyl‐protected Ribonucleosides
(Oxford University PressWiley Periodicals, Inc., 2001-12)
The [(triisopropylsilyl)oxy]methyl (TOM) group is a useful protecting group for the 2′‐OH of ribonucleosides to be used for oligoribonucleotide synthesis by the phosphoramidite method. It is completely stable to all reaction ...
Characterization of Bioeffects on Endothelial Cells Under Acoustic Droplet Vaporization.
(2014)
An ultrasound-mediated cancer treatment called gas embolotherapy has the potential for providing selective occlusion of blood vessels for therapy. Vessel occlusion is achieved by locally vaporizing micron-sized droplets ...
A study of a C Α, Β -didehydroalanine homo-oligopeptide series in the solid-state by 13 C cross-polarization magic angle spinning NMR
(John Wiley & Sons, Ltd., 2004-06)
The fully extended peptide conformation (2.0 5 -helix) has been investigated for the first time in the solid-state by 13 C cross-polarization magic angle spinning NMR. The compounds examined are members of a terminally ...
Glycosylation via Transition‐Metal Catalysis: Challenges and Opportunities
(American Chemical SocietyWiley Periodicals, Inc., 2016-10)
Synthesis of Phosphorothioate Oligonucleotides with Stereodefined Phosphorothioate Linkages
(Wiley‐Liss, 2003-09)
A method for solid‐phase synthesis of stereodefined PS‐oligos via an oxathiaphospholane approach using pure P‐diastereomers of nucleoside oxathiaphospholane monomers is described. The oxathiaphospholane monomers are ...
Chemotherapy for prostate cancer: implementing early systemic therapy to improve outcomes
(Springer-Verlag, 2005-11)
Prostate cancer remains a significant health concern for men in the USA as it is a leading cancer diagnosis and a cause of death. With the use of prostate-specific antigen or screening, a stage migration has occurred with ...
Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering
(WILEY‐VCH Verlag, 2012-06)
A tissue‐engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro‐scale tissue bundles. In this study, a method combining ...
Reexamination of the Direct Electrochemical Reduction of S ‐Nitrosothiols
(WILEY‐VCH Verlag, 2013-04)
We report here on the electrochemical reduction of S ‐nitrosothiol species (RSNO). Nitric oxide (NO) is the reported common product from electrochemically reduced RSNOs at physiological pH. However, studies here at pH 7.4 ...