Now showing items 71-80 of 509
Column Chromatography
(John Wiley & Sons,, 2000-12)
Column chromatography is used extensively in nucleic acid chemistry to purify or characterize products from chemical reactions. This appendix focuses on separations using silica gel or alumina. The procedures described ...
Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme
(Springer-Verlag, 2006-07)
Purpose : This study sought to determine the maximum tolerated dose of flat-dosed vinorelbine in combination with capecitabine in patients with metastatic breast cancer. At the time of study initiation, it was anticipated ...
Modeling ssDNA electrophoretic migration with band broadening in an entangled or cross-linked network
(WILEY-VCH Verlag, 2007-08)
We use a coarse-grained model proposed by Graham and Larson based on the temporary network model by Schieber et al.. [1] to simulate the electrophoretic motion of ssDNA and corresponding band broadening due to dispersion. ...
Mechanistic investigations in α‐hydroxycarbonyls reduction by BH 4 ‐
(Gaussian, Inc.Wiley Periodicals, Inc., 2012-12)
A Base‐Labile Protecting Group (Fluorenylmethoxycarbonyl) for the 5′‐Hydroxy Function of Nucleosides
(Wiley Periodicals, Inc.IRL Press, 2000-02)
Many popular synthesis strategies look for appropriate 2′‐O‐protection methods to use in conjunction with 5′‐O‐trityl chemistry. In contrast, this unit describes the use of FMOC as a 5′‐protecting group in conjunction with ...
Preparation of 5′‐Silyl‐2′‐Orthoester Ribonucleosides for Use in Oligoribonucleotide Synthesis
(Wiley Periodicals, Inc., 2004-03)
The recent discovery that small interfering RNAs (siRNAs) induce gene suppression in mammalian cells has sparked tremendous interest in using siRNA‐based assays and high‐throughput screens to study gene function. As a ...
Integrating mass spectrometry of intact protein complexes into structural proteomics
(Wiley Periodicals, Inc., 2012-05)
Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1,3-Dipolar Cycloaddition
(WILEY-VCH Verlag, 2008-10-22)
Precise nano- and microscale control of the architecture of biodegradable biomaterials is desirable for several biotechnological applications such as drug delivery, diagnostics, and medical imaging. Herein, we combine ...
Polymeric Scaffolds for Bone Tissue Engineering
(Kluwer Academic Publishers-Plenum Publishers; Biomedical Engineering Society ; Springer Science+Business Media, 2004-03)
Bone tissue engineering is a rapidly developing area. Engineering bone typically uses an artificial extracellular matrix (scaffold), osteoblasts or cells that can become osteoblasts, and regulating factors that promote ...