Now showing items 21-30 of 133
Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models
(John Wiley & Sons, 2015-05)
In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze the phenotypic traits separately using univariate analyses and combine the test results ...
Extent and distribution of linkage disequilibrium in the Old Order Amish
(Wiley Subscription Services, Inc., A Wiley Company, 2010-02)
Knowledge of the extent and distribution of linkage disequilibrium (LD) is critical to the design and interpretation of gene mapping studies. Because the demographic history of each population varies and is often not ...
Robust meta‐analysis of biobank‐based genome‐wide association studies with unbalanced binary phenotypes
(Wiley Periodicals, Inc.Prentice‐Hall, 2019-07)
With the availability of large‐scale biobanks, genome‐wide scale phenome‐wide association studies are being instrumental in discovering novel genetic variants associated with clinical phenotypes. As increasing number of ...
Meta-analysis of genetic association studies and adjustment for multiple testing of correlated SNPs and traits
(Wiley Subscription Services, Inc., A Wiley Company, 2010-11)
Meta-analysis has become a key component of well-designed genetic association studies due to the boost in statistical power achieved by combining results across multiple samples of individuals and the need to validate ...
Analyzing Proteinâ Protein Interactions from Affinity Purificationâ Mass Spectrometry Data with SAINT
(Wiley Periodicals, Inc., 2012-09)
Significance Analysis of INTeractome (SAINT) is a software package for scoring proteinâ protein interactions based on labelâ free quantitative proteomics data (e.g., spectral count or intensity) in affinity purificationâ ...
A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome
(Wiley Subscription Services, Inc., A Wiley Company, 2010-11)
Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of ...
Multi‐SKAT: General framework to test for rare‐variant association with multiple phenotypes
(Wiley Periodicals, Inc., 2019-02)
In genetic association analysis, a joint test of multiple distinct phenotypes can increase power to identify sets of trait‐associated variants within genes or regions of interest. Existing multiphenotype tests for rare ...
Building on the past, shaping the future: The environmental mutagenesis and genomics society
(Wiley Periodicals, Inc.Plenum Press, 2013-04)
Adaptive testing for association between two random vectors in moderate to high dimensions
(Wiley Periodicals, Inc.Department de math.; Univ. des sciences et techniques du Languedoc, 2017-11)
Testing for association between two random vectors is a common and important task in many fields, however, existing tests, such as Escoufier’s RV test, are suitable only for low‐dimensional data, not for high‐dimensional ...
SNP Prioritization Using a B ayesian Probability of Association
(Wiley Periodicals, Inc., 2013-02)
Prioritization is the process whereby a set of possible candidate genes or SNP s is ranked so that the most promising can be taken forward into further studies. In a genome‐wide association study, prioritization is usually ...