Now showing items 31-40 of 133
Comment on “Ascertainment adjustment in complex diseases”
(Wiley Subscription Services, Inc., A Wiley Company, 2002-10)
No Abstract
Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Caseâ Control Sequencing Studies
(Wiley Periodicals, Inc.Clarendon Press, 2016-09)
Rare variants (RVs) have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional singleâ marker methods for statistical ...
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases
(University of ChicagoWiley Periodicals, Inc., 2012-01)
Over the past several years, genome‐wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most of these markers confer relatively small increments ...
Optimal designs for two-stage genome-wide association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Genome-wide association (GWA) studies require genotyping hundreds of thousands of markers on thousands of subjects, and are expensive at current genotyping costs. To conserve resources, many GWA studies are adopting a ...
Quantification of cytosolic plasmid DNA degradation using high‐throughput sequencing: implications for gene delivery
(Wiley Periodicals, Inc., 2014-03)
Background Although cytosolic DNA degradation plays an important role in decreasing transgene expression, the plasmid degradation pattern remains largely unexplored. Methods Illumina dye sequencing was employed to ...
Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05)
As part of the Genetic Epidemiology Network of Arteriopathy study, hypertensive non-Hispanic White sibships were screened using 471 single nucleotide polymorphisms (SNPs) to identify genes influencing coronary artery ...
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2009-09)
Genome-wide association studies are helping to dissect the etiology of complex diseases. Although case-control association tests are generally more powerful than family-based association tests, population stratification ...
Recommended Joint and Meta‐Analysis Strategies for Case‐Control Association Testing of Single Low‐Count Variants
(Chapman and HallWiley Periodicals, Inc., 2013-09)
In genome‐wide association studies of binary traits, investigators typically use logistic regression to test common variants for disease association within studies, and combine association results across studies using ...
Haplotype association analysis for late onset diseases using nuclear family data
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
In haplotype-based association studies for late onset diseases, one attractive design is to use available unaffected spouses as controls (Valle et al. [1998] Diab. Care 21:949–958). Given cases and spouses only, the standard ...