Now showing items 41-50 of 133
Smoking and Genetic Risk Variation Across Populations of European, Asian, and African American Ancestry—A Meta‐Analysis of Chromosome 15q25
(Wiley Periodicals, Inc., 2012-07)
Quantifying and correcting for the winner's curse in quantitative-trait association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2011-04)
Quantitative traits (QT) are an important focus of human genetic studies both because of interest in the traits themselves and because of their role as risk factors for many human diseases. For large-scale QT association ...
Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II
(Springer-Verlag, 2005-02)
The current system for the classification of hereditary defects of tooth dentin is based upon clinical and radiographic findings and consists of two types of dentin dysplasia (DD) and three types of dentinogenesis imperfecta ...
Perinatal lead (Pb) exposure results in sex and tissue‐dependent adult DNA methylation alterations in murine IAP transposons
(Wiley Periodicals, Inc., 2017-10)
Epistasis among Presynaptic Serotonergic System Components
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Epistatic interactions among regulatory components of the serotonin (5-HT) neurotransmitter system may be an important aspect of 5-HT function. Because 5-HT dysregulation is associated with several common psychiatric ...
Information on ancestry from genetic markers
(Wiley Subscription Services, Inc., A Wiley Company, 2004-05)
It is possible to estimate the proportionate contributions of ancestral populations to admixed individuals or populations using genetic markers, but different loci and alleles vary considerably in the amount of information ...
Improving power for rare‐variant tests by integrating external controls
(SpringerWiley Periodicals, Inc., 2017-11)
Due to the drop in sequencing cost, the number of sequenced genomes is increasing rapidly. To improve power of rare‐variant tests, these sequenced samples could be used as external control samples in addition to control ...
Lod scores for gene mapping in the presence of marker map uncertainty
(John Wiley & Sons, Inc., 2001-07)
Multipoint lod scores are typically calculated for a grid of locus positions, moving the putative disease locus across a fixed map of genetic markers. Changing the order of a set of markers and/or the distances between the ...
SNP Set Association Analysis for Familial Data
(Springer‐VerlagWiley Periodicals, Inc., 2012-12)
Bone marrow stromal cells as a genetic platformfor systemic delivery of therapeutic proteins in vivo : human factor IX model
(John Wiley & Sons, Ltd., 2003-01)
Background Hemophilia B is an X-linked bleeding disorder that results from a deficiency in functional coagulation factor IX (hFIX). In patients lacking FIX, the intrinsic coagulation pathway is disrupted leading to a ...