Now showing items 51-60 of 133
Low molecular weight protamine as an efficient and nontoxic gene carrier: in vitro study
(John Wiley & Sons, Ltd., 2003-08)
Background The structural similarity between low molecular weight protamine (LMWP), prepared by enzymatic digestion of protamine, and HIV-TAT protein transduction peptide suggested the feasibility of LMWP as an efficient ...
Assessment of sex-specific genetic and environmental effects on bone mineral density
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09)
Although it is widely accepted that genes contribute significantly to the variation in bone mineral density (BMD), the nature of the genetic contribution is poorly defined. There are large gender differences in BMD, although ...
Brief review of regression‐based and machine learning methods in genetic epidemiology: the Genetic Analysis Workshop 17 experience
(Wiley Subscription Services, Inc., A Wiley Company, 2011)
Genetics Analysis Workshop 17 provided common and rare genetic variants from exome sequencing data and simulated binary and quantitative traits in 200 replicates. We provide a brief review of the machine learning and ...
An evaluation of the replicate pool method: quick estimation of genome-wide linkage peak p -values
(Wiley Subscription Services, Inc., A Wiley Company, 2006-05)
The calculation of empirical p -values for genome-wide non-parametric linkage tests continues to present significant computational challenges for many complex disease mapping studies. The gold standard approach is to use ...
Complex adaptive systems and human health: the influence of common genotypes of the apolipoprotein E ( ApoE ) gene polymorphism and age on the relational order within a field of lipid metabolism traits
(Springer-Verlag, 2000-11)
We analyzed the influence of age, apolipoprotein E ( ApoE ) genotype, and their interaction on the variation of each of all possible pairwise correlations among plasma levels of ApoE, ApoB, total cholesterol, triglyceride, ...
Adenovirus binding to cultured synoviocytes triggers signaling through MAPK pathways and induces expression of cyclooxygenase-2
(John Wiley & Sons, Ltd., 2005-03)
Background Recombinant adenovirus can be administered in vivo to achieve transduction of a number of cell types including human synoviocytes. Immunogenicity of adenoviruses has limited their utility as vectors for gene ...
A scan statistic for identifying chromosomal patterns of SNP association
(Wiley Subscription Services, Inc., A Wiley Company, 2006-11)
We have developed a single nucleotide polymorphism (SNP) association scan statistic that takes into account the complex distribution of the human genome variation in the identification of chromosomal regions with significant ...
Importance of Different Types of Prior Knowledge in Selecting Genome‐Wide Findings for Follow‐Up
(Wiley Periodicals, Inc.Jessica Kingsley, 2013-02)
Biological plausibility and other prior information could help select genome‐wide association ( GWA ) findings for further follow‐up, but there is no consensus on which types of knowledge should be considered or how to ...
Epigenetic responses following maternal dietary exposure to physiologically relevant levels of bisphenol A
(Wiley Subscription Services, Inc., A Wiley Company, 2012-06)
Animal studies have linked perinatal bisphenol A (BPA) exposure to altered DNA methylation, but little attention is given to analyzing multiple physiologically relevant doses. Utilizing the viable yellow agouti ( A vy ...
Mercury biomarkers and DNA methylation among michigan dental professionals
(Wiley Periodicals, Inc., 2013-04)