Now showing items 71-80 of 133
Protein Structure and Function Prediction Using I‐TASSER
(Wiley Periodicals, Inc., 2015-12)
I‐TASSER is a hierarchical protocol for automated protein structure prediction and structure‐based function annotation. Starting from the amino acid sequence of target proteins, I‐TASSER first generates full‐length atomic ...
A Variational Bayes Discrete Mixture Test for Rare Variant Association
(University College LondonWiley Periodicals, Inc., 2014-01)
Efficient Generalized Least Squares Method for Mixed Population and Family‐based Samples in Genome‐wide Association Studies
(Wiley Periodicals, Inc., 2014-07)
Genome‐wide association studies (GWAS) that draw samples from multiple studies with a mixture of relationship structures are becoming more common. Analytical methods exist for using mixed‐sample data, but few methods have ...
Genotype Imputation in Genome‐Wide Association Studies
(Wiley Periodicals, Inc., 2013-07)
Imputation is an in silico method that can increase the power of association studies by inferring missing genotypes, harmonizing data sets for meta‐analyses, and increasing the overall number of markers available for ...
A Generalized Genetic Random Field Method for the Genetic Association Analysis of Sequencing Data
(Wiley Periodicals, Inc.Springer, 2014-04)
With the advance of high‐throughput sequencing technologies, it has become feasible to investigate the influence of the entire spectrum of sequencing variations on complex human diseases. Although association studies ...
Re-examination of the historical range of the greater prairie chickenusing provenance data and DNA analysis of museum collections
(Kluwer Academic Publishers; Springer Science+Business Media, Inc., 2006-02-21)
The extent to which a species has declined within its historical range is commonly used as an important criterion in categorizing the conservation status of wild populations. The greater prairie chicken ( Tympanuchus cupido ...
Replication of genetic associations as pseudoreplication due to shared genealogy
(Wiley Subscription Services, Inc., A Wiley Company, 2009-09)
The genotypes of individuals in replicate genetic association studies have some level of correlation due to shared descent in the complete pedigree of all living humans. As a result of this genealogical sharing, replicate ...
Severe autosomal recessive retinitis pigmentosa maps to chromosome 1p13.3–p21.2 between D1S2896 and D1S457 but outside ABCA4
(Springer-Verlag, 2005-12)
A severe form of autosomal recessive retinitis pigmentosa (arRP) was identified in a large Pakistani family ascertained in the Punjab province of Pakistan. All affected individuals in the family had night blindness in early ...