Now showing items 31-40 of 439
Syndrome X: Is it for real?
(Wiley Subscription Services, Inc., A Wiley Company, 1998)
The term syndrome X has been applied to the association of hypertension, non-insulin-dependent diabetes mellitus (NIDDM), android obesity, insulin resistance, and dyslipidemia. In this paper, based on population samples ...
Understanding the accuracy of statistical haplotype inference with sequence data of known phase
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Statistical methods for haplotype inference from multi-site genotypes of unrelated individuals have important application in association studies and population genetics. Understanding the factors that affect the accuracy ...
Rederivation of Transgenic and Gene-Targeted Mice by Embryo Transfer
(Kluwer Academic Publishers-Plenum Publishers; Kluwer Academic Publishers ; Springer Science+Business Media, 2004-08)
Research on genetically engineered mice provides insights into the etiology, therapy, and genetic basis of human diseases. An important variable that affects the results of mouse studies is the health status of the animals. ...
Identifying Plausible Genetic Models Based on Association and Linkage Results: Application to Type 2 Diabetes
(Cambridge University PressWiley Periodicals, Inc., 2012-12)
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12
(Springer-Verlag, 2006-05)
Epidemiological and twin studies have consistently demonstrated a strong genetic component to prostate cancer (PCa) susceptibility. To date, numerous linkage studies have been performed to identify chromosomal regions ...
Localization of the Gene for ATP Citrate Lyase (ACLY) Distal to Gastrin (GAS) and Proximal to D17S856 on Chromosome 17q12-q21
(Elsevier, 1994-05-15)
The gene encoding ATP-citrate lyase, designated ACLY, was mapped to human chromosome 17q12-q21 by PCR on a panel of human/rodent somatic cell hybrids and localized to 17q21.1 by PCH on a panel of radiation hybrids. The ...
Mutagenicity of aliphatic epoxides
(Elsevier, 1978-11)
The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature ...
Evaluation of methods for the estimation of mutation rates in cultured mammalian cell populations
(Elsevier, 1987-04)
A systematic comparison of 5 different statistical methods for the estimation of mutation rate ([mu]) in cultured Chinese hamster V79 cells is presented. Fluctuation tests were performed with several large batches of ...
Localization of the Gene for Pigment Epithelium-Derived Factor (PEDF) to Chromosome 17p13.1 and Expression in Cultured Human Retinoblastoma Cells
(Elsevier, 1994-01-15)
The gene for pigment epithelium-derived factor (PEDF) was localized to chromosome 17 by the analysis of three independent somatic cell hybrid panels. Fluorescence in situ hybridization shows a specific hybridization signal ...
Estimating the power of variance component linkage analysis in large pedigrees
(Wiley Subscription Services, Inc., A Wiley Company, 2006-09)
Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped ...