Now showing items 131-140 of 184
Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides
(Elsevier, 1993-03)
Mouse lymphocytes in vivo or in vitro were exposed for 24 h to 4 aliphatic epoxides, glycidyl 1-naphthyl ether, glycidyl 4-nitrophenyl ether, 1-naphthylpropylene oxide and trichloropropylene oxide (TCPO), and tested for ...
Substituent effects on the genotoxicity of 4-nitrostilbene derivatives
(Elsevier, 1994-11)
4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo genotoxicity. Relative mutagenicity ...
Chromosomal aberrations in mouse lymphocytes exposed in vitro and in vivo to benzidine and 5 related aromatic amines
(Elsevier, 1994-01)
Mouse lymphocytes were exposed in vitro for 2 h or in vivo for 24 h to benzidine and related aromatic amines to test for chromosome aberrations (CA) and mitotic indices. Uninduced mouse S9 was used to activate the amines ...
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives
(Elsevier, 1993-09)
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobenzidine were compared ...
The genotoxicity of enantiomeric aliphatic epoxides
(Elsevier, 1993-01)
The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide, glycidyl 1-naphthyl ether and ...
Association between common alleles of the low-density lipoprotein receptor gene region and interindividual variation in plasma lipid and apolipoprotein levels in a population-based sample from Rochester, Minnesota
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1996-12)
This paper presents an analysis of the relationship between variation in the low-density lipoprotein receptor (LDLR) gene region and interindividual variation in plasma lipid and apolipoprotein levels in a sample representative ...
Quantitative DNA pooling to increase the efficiency of linkage analysis in autosomal dominant disease
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-02)
DNA pooling is an efficient method to rapidly perform genome-wide linkage scans in autosomal recessive diseases in inbred populations where affected individuals are likely to be homozygous for alleles near the disease gene ...
Biochemical and molecular studies of 132 patients with galactosemia
(Springer-Verlag, 1994-10)
We evaluated 132 galactosemia patients for the Q188R (glutamine-188 to arginine) mutation in the human galactose-1-phosphate uridyltransferase (GALT) gene and for GALT activity in their hemolysates by a sensitive radioisotopic ...
The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations
(Elsevier, 1990-08)
Von Recklinghausen neurofibromatosis (NF1) is one of the most common inherited human disorders. The genetic locus that harbors the mutation(s) responsible for NF1 is near the centromere of chromosome 17, within band q11.2. ...