Now showing items 91-100 of 184
Improved sib-pair linkage test for disease susceptibility loci
(Wiley Subscription Services, Inc., A Wiley Company, 1993)
An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis ...
Characterization of 10 New Polymorphic Dinucleotide Repeats and Generation of a High-Density Microsatellite-Based Physical Map of the BRCA1 Region of Chromosome 17q21
(Elsevier, 1994-12)
A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and ...
The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue
(Elsevier, 1993-04-30)
A recently reported mRNA, encoding `carbonic anhydrase-related polypeptide' (CARP) from the Purkinje cells of mouse cerebellum, was shown to have a 30-40% deduced amino acid sequence identity with the carbonic anhydrases ...
An Eco RI RFLP in the 5′ region of the human NF1 gene
(Springer-Verlag, 1993-12)
Von Recklinghausen neurofibromatosis or type l neurofibromatosis (NF1), is one of the most common autosomal dominant disorders. NF1 is characterized by neurofibromas, café-au-lait spots and Lisch nodules of the iris. The ...
Screening for steroid sulfatase (STS) gene deletions by multiplex DNA amplification
(Springer-Verlag, 1990-05)
Deletions are the most common molecular defect in steroid sulfatase (STS) deficiency. We describe the application of multiplex DNA amplification, by polymerase chain reaction, for deletion screening in patients with STS ...
DNA strand breaks in liver for four aliphatic epoxides in mice
(Elsevier, 1990-11)
Four aliphatic epoxides, 1-naphthyl glycidyl ether (NGE), 1-naphthylpropylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE), 3,3,3-trichloropropylene oxide (TCPO) and two of their precursors, 1-allylnaphthalene (AN) and ...
A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene
(Elsevier, 1992-07)
The yeast artificial chromosome (YAC) system (Burke et al., 1987, Science 236: 806-812) allows the direct cloning of large regions of the genome. A YAC contig map of approximately 700 kb encompassing the region surrounding ...
Efficient computation of patterned covariance matrix mixed models in quantitative segregation analysis
(Wiley Subscription Services, Inc., A Wiley Company, 1991)
The use of patterned covariance matrices in forming pedigree-based mixed models for quantitative traits is discussed. It is suggested that patterned covariance matrix models provide intuitive, theoretically appealing, and ...