Now showing items 101-110 of 184
On the asymmetry of biological frequency distributions
(Wiley Subscription Services, Inc., A Wiley Company, 1990)
The long-standing problem of determining whether the skewness in a sample frequency distribution is the manifestation of the intermixing of disparate groups characterizable by a normal mixture distribution or the manifestation ...
Getting to the root of plant development: the genetics of Arabidopsis root formation
(Elsevier, 1994-03)
Root development in Arabidopsis thaliana is amenable to molecular genetic analyses because of its simplicity and accessibility. Genetic screens have identified a rich collection of mutants that can be used to address a ...
A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21
(Elsevier, 1993-09)
The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed to provide a resource ...
A small plasmid for recombination-based screening
(Elsevier, 1992-12-01)
We reported recently the construction of the 4.4-kb RoK-derived pMADI plasmid carrying supF [Stewart et al., Gene 106 (1991) 97-101] that does not share nt sequences with Co1E1 and therefore permits recombination-based ...
A 530kb YAC contig tightly linked to the Friedreich ataxia locus contains five CpG clusters and a new highly polymorphic microsatellite
(Springer-Verlag, 1992-07)
Friedreich ataxia (FA) is a severe autosomal recessive neurodegenerative disease. The defective gene has been previously assigned to chromosome 9q13-q21 by demonstration of tight linkage to the two independent loci D9S15 ...
Heart development in Drosophila and vertebrates: Conservation of molecular mechanisms
(John Wiley & Sons, Inc., 1998)
Vertebrate and insect ( Drosophila ) hearts look and function quite differently from each other. Nevertheless, during embryogenesis their mesodermal origin and initial assembly into a linear heart tube are comparable in ...
Multipoint Radiation Hybrid Mapping: Comparison of Methods, Sample Size Requirements, and Optimal Study Characteristics
(Elsevier, 1994-05-01)
There are several statistical methods available for analyzing radiation hybrid (RH) data, but little is known about the ordering accuracy we can expect under common study conditions. Using analytic methods and computer ...
The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation
(Elsevier, 1990-11)
Two nonallelic mouse mutations with severe dwarf phenotypes are characterized by a lack of growth hormone, prolactin, and thyroid stimulating hormone. The cells that normally synthesize these pituitary hormones express a ...
Large-scale physical mapping within the region 22q12.3-13.1 in meningioma
(Elsevier, 1991-08)
The lack of physical mapping data strongly restricts the analysis of the meningioma chromosomal region that was assigned to the bands 22q12.3-qter. Recently, we reported a new marker D22S16 for chromosome 22 that was ...
Detection of genome similarity as an exploratory tool for mapping complex traits
(Wiley Subscription Services, Inc., A Wiley Company, 1995)
For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical ...