Now showing items 171-180 of 184
Crossovers within a short DNA sequence indicate a long evolutionary history of the APRT*J mutation
(Springer-Verlag, 1990-10)
Adenine phosphoribosyltransferase (APRT) deficiency causing 2,8-dihydroxyadenine urolithiasis and renal failure is present at a high frequency among the Japanese but not other ethnic groups. A special type of mutant allele, ...
Fluorescence in situ hybridization establishes the order cen-DXS28(C7)-DXS67(B24)-DXS68(L1)-tel in human chromosome Xp21.3
(Elsevier, 1992-06)
We report here on the order of three DNA markers, C7, B24, and L1, based on the arrangement of their fluorescently labeled hybridization sites in interphase cell nuclei. The three markers map distal to the Duchenne muscular ...
Smooth Muscle Myosin Heavy Chain Locus (MYH11) Maps to 16p13.13-p13.12 and Establishes a New Region of Conserved Synteny between Human 16p and Mouse 16
(Elsevier, 1993-10)
The human smooth myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe. ...
Kidney development branches out
(John Wiley & Sons, Inc., 1999)
For more than 40 years now, the developing kidney has served as a model paradigm for epithelial-mesenchymal interactions. The principles of inductive signaling, epithelial cell differentiation, and pattern formation are ...
Genotypes with the apolipoprotein ε4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men
(Springer-Verlag, 1996-05)
Earlier we reported that allelic variation in the gene coding for apolipoprotein (apoE) is a significant predictor of variation in the risk of coronary heart disease (CHD) death in a longitudinal study of elderly Finnish ...
DNA Sequences in the Promoter Region of the NF1 Gene Are Highly Conserved between Human and Mouse
(Elsevier, 1994-06)
The gene for type 1 neurofibromatosis (NF1) is most highly expressed in brain and spinal cord, although low levels of mRNA can be found in nearly all tissues. As a first step in investigating the regulation of NF1 gene ...
The ecology and evolution of tetracycline resistance
(Elsevier, 1992-09)
The use of tetracycline over the past few decades has been accompanied by a drastic increase in the frequency of tetracycline resistance in a wide range of bacterial species and genera. A diversity of resistance determinants ...
Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations
(Wiley Subscription Services, Inc., A Wiley Company, 1996)
We describe an extension of Risch's [(1990a,b) Am J Hum Genet 46:222–228, 229–241] method of linkage detection and exclusion for complex genetic traits. The method uses interval mapping to infer disease locus identity-by-descent ...
Nucleotide Sequence of the 18-kb Conjugative Transposon Tn916 from Enterococcus faecalis
(Elsevier, 1994-11)
Conjugative transposon Tn916 from Enterococcus faecalis DS16 encodes tetracycline resistance (Tet M) as well as determinants necessary for its own movement. Determination of the nucleotide sequence of Tn916 has been ...