Now showing items 311-320 of 338
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...
The Pharmacoepigenomics Informatics Pipeline and H-GREEN Hi-C Compiler: Discovering Pharmacogenomic Variants and Pathways with the Epigenome and Spatial Genome
(2018)
Over the last decade, biomedical science has been transformed by the epigenome and spatial genome, but the discipline of pharmacogenomics, the study of the genetic underpinnings of pharmacological phenotypes like drug ...
Statistical Methods for Large Scale Genetic Analyses
(2021)
Population scale genomic analyses have informed the development of novel therapeutics, diagnostics, and understanding of disease etiology. Among the recent developments in human genetic association analyses, electronic ...
A Longitudinal and Transancestral Analysis of DNA Methylation Patterns in Systemic Lupus Erythematosus
(2022)
Objective: Systemic lupus erythematosus (SLE or lupus) is a complex heterogeneous autoimmune disease that can affect multiple organ systems. Lupus predominantly affects women, with African-American women carrying higher ...
Epigenomic and Transcriptomic Profiling for the Study of Monogenic and Polygenic Traits and Disease
(2020)
Many trait-associated genomic loci are in non-coding regions of the genome. Determining which genetic variants in these regions are causally related to a trait and elucidating their downstream effects can be difficult. ...
Exploring the Function of Polyphosphate in the Contact Pathway of Blood Clotting and Developing Polyphosphate Probes for Enhanced Specificity
(2021)
The classic coagulation cascade has been well-studied for many years. In the traditional “waterfall” model, both the contact pathway and the tissue factor pathway can trigger blood clotting. The contact pathway is composed ...
Identification and Functional Annotation of Alternatively Spliced Isoforms
(2017)
Alternative splicing is a key mechanism for increasing the complexity of transcriptome and proteome in eukaryotic cells. A large portion of multi-exon genes in humans undergo alternative splicing, and this can have significant ...
Statistical Methods in Population Genetics for Next-Generation Sequencing Data
(2016)
The increasing number of large-scale sequencing studies has provided unprecedented access to rare genetic variation. Rare variants are often population specific and arose recently, giving unique insight into recent population ...
Identifying Novel Targetable Genes and Pathways in Cancer by Integrating Diverse Omics Data.
(2014)
Omics technologies for high-throughput profiling of human genome, transcriptome and proteome are revolutionizing cancer research and driving a paradigm shift in clinical care, from “one size” fits all treatments to molecularly ...
Roles of HSB-1 in Regulation of Heat Shock Factor Activity, Histone Levels, Mitochondrial Function and Longevity
(2019)
Signaling pathways that are involved in stress resistance have often been implicated in the regulation of the rate of aging in normal physiological conditions. The evolutionarily conserved transcription factor heat shock ...