Now showing items 321-330 of 338
Novel Mechanisms that Antagonize Hedgehog Signaling at the Cell Surface During Vertebrate Embryogenesis
(2017)
Hedgehog (HH) signaling is a conserved mode of cell-cell communication that is indispensible for embryogenesis. HH proteins are secreted ligands that travel over long distances within a developing tissue to induce distinct ...
Analysis of Long Range Gene Regulation in Drosophila; Insights from the dPax2 sparking Enhancer.
(2012)
Enhancers, a subclass of cis-regulatory sequences control gene expression and patterning during development. As enhancers are often located at considerable genomic distances from their target genes, distal enhancer promoter ...
The Role of Long Noncoding RNA SChLAP1 in Prostate Cancer
(2017)
Prostate cancer is the most common malignancy in U.S. men, accounting for nearly 30,000 deaths annually. While the majority of prostate cancers are indolent, a subset of patients has aggressive disease. However, the molecular ...
Symmetric Neural Progenitor Divisions Require Chromatin-Mediated Homology-Directed DNA Repair
(2021)
The cerebral cortex is generated by a highly coordinated series of cellular proliferations, beginning with symmetric neural progenitor cell (NPC) divisions to expand the pool of progenitors, and subsequent asymmetric NPC ...
Getting "Under the Skin": Human Social Genomics in the Multi-Ethnic Study of Atherosclerosis
(2017)
The field of human social genomics examines the role of gene expression as a biological mediator in the relationship between the social environment and health. As many studies in this field have been small, lacked replication, ...
Beyond the Transcriptome: Facilitating Interpretation of Epigenomics and Metabolomics Data
(2017)
High-throughput omics experiments produce an incredible amount of data which must be put into context to make it useful. This is true of transcriptomics assays, epigenomics assays such as those measuring transcription ...
Autophagy and Cell-Autonomy in Mouse Models of PI(3,5)P2 Deficiency
(2013)
FIG4 is the 5-phosphatase required for synthesis and turnover of the membrane signaling lipid PI(3,5)P2 (phosphatidylinositol-(3,5)-bisphosphate). Mutation of Fig4 causes neurodegeneration in mice and the neuropathy ...
How a Novel Zinc Finger Domain Improves Target Gene Selection by TCF in WNT/ß-Catenin Signaling.
(2014)
The Wnt/beta-catenin pathway is a highly conserved signaling pathway that plays an important role in metazoan development. T-cell factors (TCF) are transcription factors that regulate the transcription of many Wnt target ...
Regulatory Signaling Networks Governing Budding Yeast Filamentous Growth.
(2014)
In response to specific stresses, the budding yeast Saccharomyces cerevisiae undergoes a morphogenetic program wherein cells elongate and interconnect, forming pseudohyphal filaments. This filamentous growth transition has ...
There and Back Again: Regulation of Stem Cell Homeostasis and Dedifferentiation in the Drosophila Male Germline by me31b
(2021)
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. However, even stem cells can be damaged or lost, leading to a tissue that ...