Now showing items 331-338 of 338
Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity
(2017)
FoxO transcription factors promote longevity across diverse organisms through upregulation of
parallel stress responses. Therefore, understanding how FoxO activity is regulated may provide
insights for improving overall ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Methods for statistical and population genetics analyses.
(2011)
Genetics studies have advanced rapidly, from candidate region studies to genome wide association studies (GWAS) and next generation sequencing projects. The emergence of new technologies has brought with it an array of ...
Regulation of Bone Formation and Pathology by Local Actions of Leptin in the Bone Marrow.
(2011)
Site-specific adipose content of the bone marrow has been noted since the inclusion
of meat into the hominid diet, evidenced by marrow removal from ungulate limb
bones, 2.6 million years ago. Association between marrow fat ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
The Landscape of C. elegans 3'UTRs.
(2011)
The 3’ untranslated regions (3’UTRs) of mRNAs have recently been shown to play major roles in gene regulation by interaction with small (21-26nt length) RNAs, such as microRNAs and small interfering RNAs (siRNAs). Recent ...
Integrative Statistical Learning with Applications to Predicting Features of Diseases and Health.
(2011)
This dissertation develops methods of integrative statistical learning to studies of two human
diseases - respiratory infectious diseases and leukemia. It concerns integrating statistically
principled approaches to connect ...