Now showing items 881-890 of 945
A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men
(Elsevier, 1992)
We studied the effect of imipramine (IMI) on thyroid releasing hormone (TRH)-induced urinary urgency as a way of investigating the mechanism of the beneficial effect of IMI on enuresis. In a double-blind study, 12 normal, ...
Integrated Mapping Analysis of the Werner Syndrome Region of Chromosome 8
(Elsevier, 1994-09-01)
The Werner syndrome locus (WRN) is located at 8p11-p12. To facilitate eventual cloning of the WRN gene, a 10,000-rad radiation-reduced hybrid (RH) cell panel was generated to map genetic markers, sequence-tagged sites ...
Crossovers within a short DNA sequence indicate a long evolutionary history of the APRT*J mutation
(Springer-Verlag, 1990-10)
Adenine phosphoribosyltransferase (APRT) deficiency causing 2,8-dihydroxyadenine urolithiasis and renal failure is present at a high frequency among the Japanese but not other ethnic groups. A special type of mutant allele, ...
Fluorescence in situ hybridization establishes the order cen-DXS28(C7)-DXS67(B24)-DXS68(L1)-tel in human chromosome Xp21.3
(Elsevier, 1992-06)
We report here on the order of three DNA markers, C7, B24, and L1, based on the arrangement of their fluorescently labeled hybridization sites in interphase cell nuclei. The three markers map distal to the Duchenne muscular ...
Distribution of GABA A and GABA B receptors in mammalian brain: Potential targets for drug development
(Wiley Subscription Services, Inc., A Wiley Company, 1990)
GABA is the major inhibitory neurotransmitter in mammalian brain. GABA receptors and the metabolism of GABA are significant targets for new centrally acting drugs to treat neurological and behavioral disorders. The simple ...
Smooth Muscle Myosin Heavy Chain Locus (MYH11) Maps to 16p13.13-p13.12 and Establishes a New Region of Conserved Synteny between Human 16p and Mouse 16
(Elsevier, 1993-10)
The human smooth myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe. ...
Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats
(Springer-Verlag, 1991-04)
This experiment was designed to characterize the withdrawal syndrome produced by discontinuation of treatment with escalating, non-neurotoxic doses of d -amphetamine (AMPH). AMPH withdrawal was associated with both transient ...
Preparation and characterization of high-surface-area polymer substrates for microcalorimetry
(John Wiley & Sons, Inc., 1996-05)
The preparation and characterization of high-surface-area polymeric substrates suitable for the microcalorimetry of protein adsorption are described. High-surface-area polystyrene, poly(styrene- co -butyl methacrylate) and ...
Regulation of Chemokine Production by the Oxidative Metabolism of L-Arginine in a Human Mixed Lymphocyte Reaction
(Elsevier, 1994-06)
Previous studies have shown that during the development of a mixed lymphocyte reaction (MLR) levels of the chemotactic cytokines IL-8 and MCP-1 (members of the C-X-C and C-C supergene families, respectively) increase in a ...
ACE Inhibitors in Heart Failure: Prospects and Limitations
(Kluwer Academic Publishers; Springer Science+Business Media, 1997-05)
ACE inhibitors have been shown to be effective in reducing the morbidity and mortality of patients with left ventricular systolic dysfunction, but their application to clinical practice in this situation is still limited. ...