Now showing items 911-920 of 945
Clozapine's functional mesolimbic selectivity is not duplicated by the addition of anticholinergic action to haloperidol: a brain stimulation study in the rat
(Springer-Verlag, 1993-01)
This study examined whether the anticholinergic potency of the clinically superior antipsychotic drug clozapine contributes to clozapine's anatomically-selective functional inhibition of the mesolimbic dopamine (DA) system, ...
Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists
(Springer-Verlag, 1994-05)
The discriminative stimulus effects of several μ-opioid agonists were examined under conditions of opioid sensitization or tolerance, i.e., before and after 1-week SC infusions of naloxone or μ-opioid agonists. Rats were ...
Capabilities of two- and three-dimensional FDG-PET for detecting small lesions and lymph nodes in the upper torso: a dynamic phantom study
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-01)
The capabilities and limitations of two-(2D) and three-dimensional (3D) fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting small tumors and lymph nodes were studied in a phantom modeling the ...
Nucleotide Sequence of the 18-kb Conjugative Transposon Tn916 from Enterococcus faecalis
(Elsevier, 1994-11)
Conjugative transposon Tn916 from Enterococcus faecalis DS16 encodes tetracycline resistance (Tet M) as well as determinants necessary for its own movement. Determination of the nucleotide sequence of Tn916 has been ...
Local administration of Δ9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-04)
Rationale: Cannabinoids can reduce nociceptive responses by acting on peripheral cannabinoid receptors in rodents. Objectives: The study was conducted to evaluate the hypothesis that local administration of Δ 9 ...
VCAM-1 influences Lymphocyte Proliferation and Cytokine Production during Mixed Lymphocyte Responses
(Elsevier, 1994-03)
The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule ...
Tumor-specific granulocyte/macrophage colony-stimulating factor and interferon γ secretion is associated with in vivo therapeutic efficacy of activated tumor-draining lymph node cells
(Springer-Verlag, 1995-09)
In this study, cytokine release by tumor-draining lymph node cells sensitized in vitro (IVS-TDLN) was examined and correlated with therapeutic efficacy in adoptive immunotherapy. Mice bearing immunologically distinct MCA ...
Identifying influential individuals in linkage analysis: Application to a quantitative trait locus detected in the COGA data
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
Once linkage is detected to a quantitative trait locus (QTL), the next step towards localizing the gene involved may be to identify those families, or individuals, in whom the putative mutations are segregating. In this ...
Competitive Inhibition of p -Aminohippurate Transport by Quinapril in Rabbit Renal Basolateral Membrane Vesicles
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1998-06)
The mechanism of quinapril's interaction with the organic anion transporter was characterized by studying its effect on the transport of p -aminohippurate (PAH) in rabbit renal basolateral membrane vesicles (BLMV). ...
Monte Carlo analysis of the backscattering of radiation from a sphere to a plane
(Elsevier, 1990-02)
A Monte Carlo method is described for computing the backscattering of radiation from a sphere situated above an emitting plane. Numerical results are given and compared with analytic bounds for this problem which were ...