Now showing items 481-483 of 483
Fast Capillary Electrophoresis for the Study of Dopamine in the Central Nervous System.
(2011)
The study of neurochemical events in the central nervous system (CNS) with temporal resolution ranging from seconds to minutes facilitates the evaluation of intercellular communication on times scales that are relevant to ...
A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.
(2011)
Predicting and controlling the systemic and local pharmacokinetics of pulmonary medications in different regions of the lung is critical for optimizing the efficacy and safety of inhaled drugs. Here, a modular, multiscale, ...
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.
(2012)
MLL1 is a histone-3 lysine-4 (H3K4) methyltransferase, which is misregulated in patients with leukemia and linked with tumorigenicity through upregulation of the target genes HoxA9 and Meis-1. Suppressing expression of ...