Now showing items 22061-22070 of 22088
Optimizing Repetitive Transcranial Magnetic Stimulation Protocols for Motor Function
(2024)
Humans are incredibly adept at reaching for and manipulating objects – tasks vital for daily activities of independent living. Restoration of motor function after a neurological disorder like Parkinson’s disease or stroke ...
Immuno-therapeutics Modulating B Immunity Against Cancer
(2024)
Vaccines activating B cell to mount robust antigen specific humoral immunity against foreign pathogens, like SARS-CoV-2 virus, influenza virus, human papillomavirus., have achieved tremendous clinical success. However, the ...
Development and Validation of Transportable, Clinically Applicable and Scalable Machine Learning Models for Acute Kidney Injury
(2024)
Acute kidney injury (AKI), a frequent complication in hospitalized patients, poses significant challenges due to its high incidence, short-term mortality, and substantial economic burden. Current AKI models utilizing ...
Evaluation of Lipid-Based Nanoparticles for the Treatment of Cardiovascular Diseases
(2024)
Nearly 17.9 million people die every year from cardiovascular-related diseases, which accounts for 31% of all deaths worldwide. Endogenous high-density lipoproteins (HDL) are natural cardioprotective particles that have ...
Auditory Cortical Ensemble-Mechanisms Facilitating Auditory-Driven Behaviors and Perception
(2023)
Sounds in our everyday environment play a crucial role in guiding our perception and behaviors. The ability to effectively process these sounds—perceive them, contextualize their meaning, and subsequently harness this ...
Operant Conditioning of Corticospinal Pathways Following Anterior Cruciate Ligament Reconstruction and Total Knee Arthroplasty
(2023)
Reduced corticospinal excitability has been theorized to contribute to quadriceps dysfunction after knee injury and surgery. Current rehabilitation methods do not directly target corticospinal pathways, which may limit ...
Home-based Therapeutic Drug Monitoring for Patient-Centric Precision Dosing of Immunosuppression after Solid Organ Transplantation
(2024)
The lifesaving potential of organ transplantation depends on the individualization of immunosuppressive drugs. Precision dosing is critical to prevent immune-mediated damage while minimizing toxicity. Precise dosing for ...
Critical Race Approaches to Understanding Health Inequities Impacting Trans People of Color in the United States
(2024)
This dissertation critically examines structural drivers of health inequities impacting trans people of color in the United States. To do so, I use theories that concern how the structural power dynamics that drive these ...
Investigating the Interplay of Mitochondrial Dynamics and Proteostasis during Neuronal Ischemia/Reperfusion Injury using Integrated Imaging and Modeling Approaches
(2024)
Cerebral ischemia/reperfusion (I/R) injuries, including stroke and cardiac arrest can lead to irreversible neuronal damage and neurological complications. Mitochondrial damage and dysfunction are critical components of ...
The Public Health Consequences of Compounding Disasters and Colonialism in Puerto Rico: A Mixed-Methods Investigation
(2024)
In recent decades, the ongoing climate crisis has disproportionately impacted historically marginalized populations globally through environmental hazards and disasters. Understanding the health impacts of multiple disaster ...