Now showing items 91-100 of 265
Aggression, anxiety and vocalizations in animals: GABA A and 5-HT anxiolytics
(Springer-Verlag, 1995-09)
A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. ...
Effects of N,N-dimethyltryptamine on electrically evoked responses in the cat visual system and modification by neuroleptic agents,
(Elsevier, 1976-09)
The effects of N,N-dimethyltryptamine on electrically evoked potentials in the visual system of the cat and the interaction of selected neuroleptic agents with dimethyltryptamine were studied. Dimethyltryptamine caused a ...
Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
(Springer-Verlag, 2005-09)
Drug challenges in “intact” and p -chlorophenylalanine ( p -CPA)-treated animals can be used to distinguish agents that act as direct serotonin (5-HT) agonists from agents that function as 5-HT releasers.
Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy
(Elsevier, 1983)
1. 1. Specific binding of 3H-clonidine to alpha2 adrenoreceptors upon human blood platelet membranes is increased in patients with major depressive disorder (endogenous depression).2. 2. Specific binding of 3H-yohimbine ...
Self-administration of fentanyl, cocaine and ketamine: effects on the pituitary–adrenal axis in rhesus monkeys
(Springer-Verlag, 2004-11)
Drugs of abuse can affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis. Acute administration of drugs that serve as reinforcers have been observed to stimulate the rat HPA axis, leading to the suggestion ...
The distribution of cholecystokinin and vasoactive intestinal peptide in rhesus monkey brain as determined by radioimmunoassay
(Elsevier, 1983-07)
The concentration of cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in dissected cortical and subcortical areas of four rhesus monkeys' brains was determined by radioimmunoassay (RIA). Cerebral cortical ...
Current benzodiazepine issues
(Springer-Verlag, 1995-03)
This article deals with some of the recent evidence bearing on the issues of the liability of benzodiazepines to lead to abuse, dependence, and adverse behavioral effects. Reviews of epidemiological, clinical and experimental ...
The effects of scopolamine hydrobromide on one-way and two-way avoidance learning in rats
(Elsevier, 1968-09)
Previous studies have shown certain striking similarities between the behavioral effects produced by some anticholinergic drugs and the effects produced by hippocampal destruction. To investigate this parallel more thoroughly, ...
Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations
(Elsevier, 1980)
Dynorphin is a recently identified, pharmacologically potent endogenous opioid peptide. Heretofore it has not been characterized for its behavioral effects. The effects of centrally infused dynorphin upon a variety of ...
Y-Maze behavior after an analog of ACTH 4-9, evidence for an attentional alteration
(Springer-Verlag, 1980-11)
Adult, male, Swiss-Webster mice were injected with either control solution or various doses of a long-acting analog of ACTH 4-9. The drug produced significant alterations in performance in an equiangular Y-maze. In comparison ...