Now showing items 41-50 of 265
Effects of physostigmine on brain acetylcholine content and release
(Elsevier, 1973-01)
The content and release of acetylcholine (ACh) from cat brain and ACh content of rat brain was measured using the frog rectus and leech muscle bioassays before and after physostigmine 100 [mu]g/kgi.v. or i.p. The drug ...
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats
(Springer-Verlag, 1987-09)
Directly observable behavioral effects of the N-methyl- D -aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (AP5) (10–1,000 mg/kg IP, 0.18–5.6 μmol/rat ICV) and of phencyclidine (PCP) (3.2–56 mg/kg IP, ...
Effects of stress and REM sleep deprivation on the patterns of avoidance learning and brain acetylcholine in the mouse
(Springer-Verlag, 1973-12)
Pure bred DBA/2J mice were subjected to varying degrees of stress and “water tank” REM sleep deprivation using one-animal cages, large platforms and/or poles. Subsequently, the animals were studied for acquisition, short-term ...
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons
(Springer-Verlag, 1985-03)
Six pigeons, trained to peck a response key on a fixed-ratio 20 schedule of food reinforcement, were used to examine the effects of morphine, naltrexone, and dextrorphan, before, during, and after chronic treatment with ...
Effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior
(Springer-Verlag, 1976-01)
The effects of anti-agressive agent Sch 12679 were evaluated upon stable baselines of rage and predation elicited by electrical stimulation of the hypothalamus in cats. Sch 12679 depressed approach and terminal aspects of ...
Dynorphin reduces voltage-dependent calcium conductance of mouse dorsal root ganglion neurons
(Elsevier, 1984-12)
Dynorphin A (DYN) (1 [mu]M) decreased somatic calcium-dependent action potential (CAP) duration of a portion of dorsal root ganglion (DRG) neurons in a naloxone reversible manner. Responses to DYN differed from responses ...
Lithium and the structure of exploratory behavior in the rat
(Elsevier, 1980)
1. 1. Adult male Sprague Dawley rats were given lithium as a dietary supplement, or a control diet.2. 2. A single seven hour test of exploratory behavior was carried out after one week of chronic drug exposure.3. 3. The ...
Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward
(Springer-Verlag, 1978-01)
Three centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C.2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rates of responding for ...
Fenfluramine and N-ethyl amphetamine: Comparison of the reinforcing and rate-decreasing actions in the rhesus monkey
(Springer-Verlag, 1975-01)
N-ethyl amphetamine HCl (NEA) and fenfluramine HCl ( meta -trifluoromethyl N-ethyl amphetamine) were evaluated as reinforcers in rhesus monkeys that had been previously trained to press a lever using food presentations and ...
Grooming elicited by intracerebroventricular bombesin and eledoisim in the mouse
(Elsevier, 1980-01)
The behavioral effects of centrally administered bombesin and eledolsin were investigated in the mouse. Both peptides produced syndromes of compulsive stereotyped grooming. Manipulations known to affect other forms of ...