Now showing items 37281-37290 of 37589
Bayesian Methods for snSMART Designs with External Controls and Dynamic Prediction of Landmark Survival Time in Cancer Clinical Trials
(2024)
In Duchenne muscular dystrophy (DMD) and other rare diseases, recruiting patients into clinical trials is challenging. Additionally, assigning patients to long-term, multi-year placebo arms raises ethical and trial retention ...
Machine Learning for Healthcare: Model Development and Implementation in Longitudinal Settings
(2024)
Despite great promise, developing and implementing machine learning (ML) models for healthcare remains a challenging engineering task. The progression of disease generates complex longitudinal data that can be difficult ...
Factors associated with mobile app-based ordering of HIV self-test kits among men who have sex with men in Atlanta, Detroit and New York City: an exploratory secondary analysis of a randomized control trial
(Wiley Periodicals, Inc.Pew Research Center, 2023-05)
IntroductionThe United States Centers for Disease Control and Prevention currently recommends HIV screening at least annually among sexually active gay, bisexual and other men who have sex with men (MSM), but only half ...
Type of syncope and outcome in Brugada syndrome: A systematic review and meta-analysis
(Wiley Periodicals, Inc., 2023-04)
IntroductionBrugada syndrome is an inherited arrhythmic disease associated with major arrhythmic events (MAE). The importance of primary prevention of sudden cardiac death (SCD) in Brugada syndrome is well recognized; ...
Measurement differences in the assessment of functional limitations for cognitive impairment classification across geographic locations
(American Psychiatric AssociationWiley Periodicals, Inc., 2023-05)
IntroductionThe measurement of dementia in cross-national contexts relies on the assessment of functional limitations. We aimed to evaluate the performance of survey items on functional limitations across culturally diverse ...
The patterns and diagnostic significance of the lack of surface immunoglobulin light chain on mature B cells in clinical samples for lymphoma workup
(John Wiley & Sons, Inc., 2023-05)
BackgroundSurface immunoglobulin (sIg) light chains are not always detected on mature B cells. This may present as a challenge for clonality determination in clinical flow cytometry.MethodsTo explore the mechanism and ...
The risks of misclassifying addictive food substances as non-addictive
(Wiley Periodicals, Inc., 2023-04)
Evaluation of Lipid-Based Nanoparticles for the Treatment of Cardiovascular Diseases
(2024)
Nearly 17.9 million people die every year from cardiovascular-related diseases, which accounts for 31% of all deaths worldwide. Endogenous high-density lipoproteins (HDL) are natural cardioprotective particles that have ...
Sensing Movement: Encoding of Self and External Motion by Auditory Cortical Neuronal Ensembles
(2024)
In the world, humans and animals continuously receive sensory information, decode from it information about the environment and use that information to guide survival. For each sensory modality, continuous information can ...
Home-based Therapeutic Drug Monitoring for Patient-Centric Precision Dosing of Immunosuppression after Solid Organ Transplantation
(2024)
The lifesaving potential of organ transplantation depends on the individualization of immunosuppressive drugs. Precision dosing is critical to prevent immune-mediated damage while minimizing toxicity. Precise dosing for ...