Now showing items 2941-2950 of 3003
Effects of Human Obesity-associated Mutations on Cellular Actions of the Adapter Protein SH2B1.
(2013)
Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin, insulin, growth hormone (GH), and nerve ...
Development Of An Artificial Membrane Lung
(2016)
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of death across the world. However, treatment options for end-stage COPD are extremely limited. An artificial membrane lung ...
Targeting DNA Damage, Apoptosis, and the Cell Cycle for the Radiosensitization of Aggressive Forms of Breast Cancer
(2022)
Breast cancer is the most common invasive cancer diagnosed in women, and there is a critical need to identify novel treatment strategies. To that end, therapies designed to target molecular drivers specific to individual ...
Label Uncertainty and Learning Using Partially Available Privileged Information for Clinical Decision Support: Applications in Detection of Acute Respiratory Distress Syndrome
(2021)
Artificial intelligence and machine learning have the potential to transform health care by deriving new and important insights from the vast amount of data generated during routine delivery of healthcare. The digitization ...
Prioritization of Evolutionary Events for Immune Response Studies: Introgression, Selection, and Infectious Disease Among Indigenous Americans
(2020)
A history of exposure to infectious diseases has influenced the biology of Mesoamericans. From the urbanization of Mesoamerican communities to colonial contact in the 15th century, immune response to various pathogens have ...
High-Risk Human Papillomavirus in Head and Neck Squamous Cell Carcinoma.
(2013)
High-risk human papillomavirus (hrHPV)-driven carcinogenesis is the predominant etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). Most HPV-positive OPSCCs respond well to therapy, prompting interest in ...
Acoustic Methods for Histotripsy Feedback
(2019)
Histotripsy is a therapeutic ultrasound modality that employs clouds of inertial cavitation to noninvasively destroy unwanted tissue. Histotripsy systems are, traditionally, transmit-only systems incapable of receiving ...
Reducing Maternal Mortality and Morbidity in Michigan: A Mixed Methods Analysis of the Impact of an Obstetric Hemorrhage Patient Safety Bundle
(2022)
The United States has the highest rate of maternal mortality despite outspending all other resource-rich countries in per-capita reproductive health care. Contributing to this problem are a combination of factors including ...
Changes in Spending, Risk Selection, and the Response of Frontline Clinicians: Understanding Performance Mechanisms in the Medicare Shared Savings Program
(2021)
Confronted by an increasingly expensive and fragmented health care system, public and private payers have established a series of reforms designed to lower costs and improve quality. A leading example is the Medicare Shared ...
The Role of Aconitate Decarboxylase 1 in Inflammation and Disease
(2022)
Immune cell metabolism, or immunometabolism, has recently become of interest for its role in inflammation and disease. A growing field of research has identified that metabolic rewiring and immune cell activation are ...