Now showing items 1161-1170 of 1252
Metabolism and Motility: Characterizing Metabolic Changes that Lead to Metastasis.
(2013)
Cancer is an often devastating disease that affects populations throughout the world. The major cause of cancer-related death is metastasis, not the primary tumor. By understanding changes in cancer cells that allow them ...
Molecular Pathways Modulating the Severity of IgE-mediated Anaphylaxis
(2021)
Food allergic reactions can involve cardiovascular, respiratory, cutaneous, gastrointestinal (GI) and neurologic organ systems. Clinical and experimental studies have provided corroborative evidence that upon food exposure, ...
Decrypting Intestinal Mucosal Repair
(2019)
Regeneration is a word that has inspired the imagination of artists and scientists alike ever since the word’s inception in mid-14th century from Latin meaning “being born again.” Today, medical research labs are fascinated ...
Regulation of Mesenchymal Progenitor Proliferation and Defferentiation by Thrombospondin-2 and Notch Signaling.
(2014)
Mesenchymal Stem Cells (MSC) give rise to osteoblasts, adipocytes and chondrocytes. A decrease in MSC number and a shift in their differentiation to the adipogenic fate is observed with aging and have been proposed as ...
Non-Random Sister Chromatid Segregation During Stem Cell Division in Drosophila Melanogaster Testis.
(2013)
Adult stem cells undergo asymmetric cell division to self-renew and to produce differentiated cells throughout the life of an organism. This increases the risk of replicative senescence or neoplastic transformation due to ...
The Road to Identifying Disease Causing Genes: Association Tests, Genotype Imputations, and Sampling Strategies for Sequencing Studies.
(2013)
Technological advances now allow investigators to use sequencing data to identify genetic risk variants for complex diseases. However, it is still expensive to sequence a large sample of individuals. While genotype imputation ...
Stem Cell-Based Modeling of Early Human Neural Development
(2020)
Neurulation is a key embryonic developmental process that gives rise to the formation of the neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the ...
Transforming Growth Factor-ß3 Signaling during Palatogenesis.
(2014)
The formation of the palate (palatogenesis) is a complex developmental process that when disrupted results in cleft palate, a common human birth defect, occurring in 1 out of every 2000 babies. The palate is formed from ...
Identification of PDL1 Drivers in Models of Head and Neck Squamous Cell Carcinoma by Genome Wide Screening
(2020)
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and as only approximately 50% of patients survive five years after diagnosis, new treatment options are urgently needed. A complex ...
Interactions between Hebbian and Homeostatic Synaptic Plasticity in Hippocampal Circuits.
(2014)
Hebbian forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), are thought to underlie learning and memory, but these processes may have a destabilizing effect on neural activity. ...